Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 280504..281048 Replicon chromosome
Accession NZ_CP046309
Organism Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FOC58_RS01345 Protein ID WP_003409896.1
Coordinates 280504..280800 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FOC58_RS01350 Protein ID WP_003409899.1
Coordinates 280797..281048 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC58_RS01290 275537..275887 - 351 WP_003409871.1 hypothetical protein -
FOC58_RS01295 275898..276800 - 903 WP_003899097.1 hypothetical protein -
FOC58_RS01300 276821..277012 - 192 WP_003409876.1 hypothetical protein -
FOC58_RS01305 277013..277309 - 297 WP_003409877.1 hypothetical protein -
FOC58_RS01310 277549..277764 + 216 WP_003409878.1 antitoxin -
FOC58_RS01315 277761..278072 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS20825 278046..278567 - 522 WP_003904745.1 hypothetical protein -
FOC58_RS01325 278542..278919 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FOC58_RS01330 278961..279410 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FOC58_RS01335 279407..279952 + 546 WP_003409891.1 SecB-like chaperone -
FOC58_RS01340 279841..280455 - 615 WP_003901296.1 hypothetical protein -
FOC58_RS01345 280504..280800 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC58_RS01350 280797..281048 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FOC58_RS01355 281035..281529 + 495 WP_003899099.1 hypothetical protein -
FOC58_RS01360 281689..282096 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FOC58_RS01365 282100..282372 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC58_RS01370 282405..283625 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FOC58_RS01375 284524..285321 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T143944 WP_003409896.1 NZ_CP046309:c280800-280504 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T143944 NZ_CP061519:540497-540679 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT143944 WP_003409899.1 NZ_CP046309:c281048-280797 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT143944 NZ_CP061519:540772-541176 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References