Detailed information of TA system TA143942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 271467..272170
• Replicon: chromosome
• Accession: NZ_CP046309
• Organism: Mycobacterium tuberculosis strain FDAARGOS_750

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FOC58_RS01255
• Protein ID: WP_155936521.1
• Coordinates: 271467..271796 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: G0TLK8
• Locus tag: FOC58_RS01260
• Protein ID: WP_003409780.1
• Coordinates: 271793..272170 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC58_RS01235	267850..268920	+	1071	WP_003899091.1	epoxide hydrolase EphB	-
FOC58_RS01240	268917..269432	+	516	WP_003409718.1	flavin reductase family protein	-
FOC58_RS01245	269429..270490	+	1062	WP_003899092.1	3,4-dihydroxy-2-butanone-4-phosphate synthase	-
FOC58_RS01250	270487..271257	+	771	WP_003409775.1	SDR family oxidoreductase	-
FOC58_RS01255	271467..271796	-	330	WP_155936521.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FOC58_RS01260	271793..272170	-	378	WP_003409780.1	type II toxin-antitoxin system antitoxin MazE5	Antitoxin
FOC58_RS01265	272167..272757	-	591	WP_003409784.1	SEC-C domain-containing protein	-
FOC58_RS01270	272812..274176	+	1365	WP_003903691.1	HNH endonuclease	-
FOC58_RS01275	274331..274783	-	453	WP_003899095.1	lipoprotein	-
FOC58_RS01280	274847..275248	+	402	WP_003409869.1	hypothetical protein	-
FOC58_RS01285	275241..275423	-	183	WP_003409870.1	hypothetical protein	-
FOC58_RS01290	275537..275887	-	351	WP_003409871.1	hypothetical protein	-
FOC58_RS01295	275898..276800	-	903	WP_003899097.1	hypothetical protein	-
FOC58_RS01300	276821..277012	-	192	WP_003409876.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 11803.88 Da
• Isoelectric Point: 8.3666

>T143942 WP_155936521.1 NZ_CP046309:c271796-271467 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCCR

Nucleotide

• Length: 330 bp

>T143942 NZ_CP061517:1308801-1308983 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13560.07 Da
• Isoelectric Point: 5.1519

>AT143942 WP_003409780.1 NZ_CP046309:c272170-271793 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Nucleotide

• Length: 378 bp

>AT143942 NZ_CP061517:1309076-1309480 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Antitoxin

• AlphaFold DB: G0TLK8