Detailed information of TA system TA143939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4330995..4331563
• Replicon: chromosome
• Accession: NZ_CP046308
• Organism: Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TH08
• Locus tag: FOC59_RS20365
• Protein ID: WP_003405865.1
• Coordinates: 4331189..4331563 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TH07
• Locus tag: FOC59_RS20360
• Protein ID: WP_003405863.1
• Coordinates: 4330995..4331192 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC59_RS20340	4327036..4327674	-	639	WP_003898730.1	lipid droplet-associated protein	-
FOC59_RS20345	4327764..4328771	+	1008	WP_003405853.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
FOC59_RS20350	4328788..4329771	-	984	WP_003903326.1	hypothetical protein	-
FOC59_RS20355	4329834..4330907	+	1074	WP_003898732.1	redox-regulated ATPase YchF	-
FOC59_RS20360	4330995..4331192	+	198	WP_003405863.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FOC59_RS20365	4331189..4331563	+	375	WP_003405865.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC59_RS20370	4331766..4332464	+	699	WP_003898733.1	hypothetical protein	-
FOC59_RS20375	4332582..4332767	+	186	WP_003901093.1	hypothetical protein	-
FOC59_RS20380	4332694..4332969	-	276	WP_003405867.1	hypothetical protein	-
FOC59_RS20385	4333212..4333535	+	324	WP_003405871.1	antibiotic biosynthesis monooxygenase	-
FOC59_RS20390	4333550..4334260	-	711	WP_003911399.1	hypothetical protein	-
FOC59_RS21175	4334282..4334491	+	210	WP_003911400.1	hypothetical protein	-
FOC59_RS20395	4334443..4335150	-	708	Protein_3983	adenylate/guanylate cyclase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13444.56 Da
• Isoelectric Point: 5.1881

>T143939 WP_003405865.1 NZ_CP046308:4331189-4331563 [Mycobacterium tuberculosis]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Nucleotide

• Length: 375 bp

>T143939 NZ_CP061517:448336-448725 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 6973.03 Da
• Isoelectric Point: 11.7327

>AT143939 WP_003405863.1 NZ_CP046308:4330995-4331192 [Mycobacterium tuberculosis]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Nucleotide

• Length: 198 bp

>AT143939 NZ_CP061517:448084-448329 [Acinetobacter baumannii]
ATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTTTGACCCTTATGT
GAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAGACCCTGATTTAC
TAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAACACTATGTTCAT
GGTTAA

Structures

Toxin

• AlphaFold DB: G0TH08

Antitoxin

• AlphaFold DB: G0TH07