143938

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4322239..4322870 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FOC59_RS20310 Protein ID WP_003405820.1
Coordinates 4322239..4322550 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FOC59_RS20315 Protein ID WP_003405836.1
Coordinates 4322550..4322870 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS20290 4317720..4319144 - 1425 WP_003405805.1 class II fumarate hydratase -
FOC59_RS20295 4319175..4320263 - 1089 WP_017351234.1 class II fructose-bisphosphatase -
FOC59_RS20300 4320319..4320963 + 645 WP_003915494.1 DUF4245 domain-containing protein -
FOC59_RS20305 4320970..4322127 - 1158 WP_003898727.1 AI-2E family transporter -
FOC59_RS20310 4322239..4322550 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FOC59_RS20315 4322550..4322870 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FOC59_RS20320 4322880..4324405 + 1526 Protein_3967 carboxylesterase/lipase family protein -
FOC59_RS20325 4324423..4325535 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FOC59_RS20330 4325545..4325802 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FOC59_RS20335 4325792..4327039 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FOC59_RS20340 4327036..4327674 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T143938 WP_003405820.1 NZ_CP046308:c4322550-4322239 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T143938 NZ_CP061516:c54641-54282 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT143938 WP_003405836.1 NZ_CP046308:c4322870-4322550 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT143938 NZ_CP061516:c54282-53983 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References