Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 3847905..3848697 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag FOC59_RS17925 Protein ID WP_003403386.1
Coordinates 3848260..3848697 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag FOC59_RS17920 Protein ID WP_003403381.1
Coordinates 3847905..3848150 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17890 3842925..3844430 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FOC59_RS17895 3844511..3845521 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
FOC59_RS17900 3845909..3846292 - 384 WP_003403365.1 ribonuclease VapC6 -
FOC59_RS17905 3846387..3846542 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
FOC59_RS17910 3846618..3847334 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
FOC59_RS17915 3847610..3847918 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC59_RS17920 3847905..3848150 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
FOC59_RS17925 3848260..3848697 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS17930 3848694..3848948 - 255 WP_003911263.1 antitoxin VapB7 -
FOC59_RS17935 3849062..3851425 + 2364 WP_003403397.1 arylsulfatase AtsD -
FOC59_RS17940 3851488..3851814 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC59_RS17945 3851726..3852064 + 339 WP_003403405.1 PIN domain-containing protein -
FOC59_RS17950 3852061..3852234 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T143932 WP_003403386.1 NZ_CP046308:c3848697-3848260 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T143932 NZ_CP061513:c491155-490904 [Morganella morganii]
ATGAAAACATTAACATACAGTGAAGTGCGCCAAAATCTCACCGCTGCGATGAATGAAACAGTGGATGACCGTATCCCTAT
TTTAATCACACGGCAGAAAGGTACTGCATGCGTATTACTATCACTTGATGAATATCAGTCTCTGGAAGAGACCGCCTATC
TGATGCGTTCGCCGAATAACGCACGGCGTTTAATGGATTCCATTGACGAATTAAATGCCGGAAAGGGGCTCAAAAAGGAA
ATCAATGAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT143932 WP_003403381.1 NZ_CP046308:c3848150-3847905 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT143932 NZ_CP061513:c490907-490653 [Morganella morganii]
ATGACATTGACGTTTTCGTCTCAGGCATGGGAAGACTATCTGTACTGGCAAAATACAGATAAAAAAACGCTCAGACGTAT
CAATGAACTAATTAAAGCCGCACAGAGAACACCTTTCACAGGCATCGGAAAACCGGAACCACTGAAAAATAATCTTTCCG
GCTGGTGGTCGCGGCGGATAACGGAAGAACACCGGCTGGTTTACCGTGTTACTAACCAGGGAGTTGAGGTGGCTGCCTGC
CGGTACCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References