Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3847610..3848150 | Replicon | chromosome |
Accession | NZ_CP046308 | ||
Organism | Mycobacterium tuberculosis strain FDAARGOS_751 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P9WII0 |
Locus tag | FOC59_RS17915 | Protein ID | WP_003403376.1 |
Coordinates | 3847610..3847918 (-) | Length | 103 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TQE0 |
Locus tag | FOC59_RS17920 | Protein ID | WP_003403381.1 |
Coordinates | 3847905..3848150 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC59_RS17890 | 3842925..3844430 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
FOC59_RS17895 | 3844511..3845521 | + | 1011 | WP_031653722.1 | ABC transporter ATP-binding protein | - |
FOC59_RS17900 | 3845909..3846292 | - | 384 | WP_003403365.1 | ribonuclease VapC6 | - |
FOC59_RS17905 | 3846387..3846542 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
FOC59_RS17910 | 3846618..3847334 | - | 717 | WP_003903122.1 | CPBP family intramembrane metalloprotease | - |
FOC59_RS17915 | 3847610..3847918 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
FOC59_RS17920 | 3847905..3848150 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
FOC59_RS17925 | 3848260..3848697 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | - |
FOC59_RS17930 | 3848694..3848948 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
FOC59_RS17935 | 3849062..3851425 | + | 2364 | WP_003403397.1 | arylsulfatase AtsD | - |
FOC59_RS17940 | 3851488..3851814 | + | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
FOC59_RS17945 | 3851726..3852064 | + | 339 | WP_003403405.1 | PIN domain-containing protein | - |
FOC59_RS17950 | 3852061..3852234 | + | 174 | WP_003898549.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11320.10 Da Isoelectric Point: 11.6554
>T143931 WP_003403376.1 NZ_CP046308:c3847918-3847610 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC
Download Length: 309 bp
>T143931 NZ_CP061513:c490907-490653 [Morganella morganii]
ATGACATTGACGTTTTCGTCTCAGGCATGGGAAGACTATCTGTACTGGCAAAATACAGATAAAAAAACGCTCAGACGTAT
CAATGAACTAATTAAAGCCGCACAGAGAACACCTTTCACAGGCATCGGAAAACCGGAACCACTGAAAAATAATCTTTCCG
GCTGGTGGTCGCGGCGGATAACGGAAGAACACCGGCTGGTTTACCGTGTTACTAACCAGGGAGTTGAGGTGGCTGCCTGC
CGGTACCATTATTGA
ATGACATTGACGTTTTCGTCTCAGGCATGGGAAGACTATCTGTACTGGCAAAATACAGATAAAAAAACGCTCAGACGTAT
CAATGAACTAATTAAAGCCGCACAGAGAACACCTTTCACAGGCATCGGAAAACCGGAACCACTGAAAAATAATCTTTCCG
GCTGGTGGTCGCGGCGGATAACGGAAGAACACCGGCTGGTTTACCGTGTTACTAACCAGGGAGTTGAGGTGGCTGCCTGC
CGGTACCATTATTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9169.01 Da Isoelectric Point: 4.2070
>AT143931 WP_003403381.1 NZ_CP046308:c3848150-3847905 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
Download Length: 246 bp
>AT143931 NZ_CP061513:c491155-490904 [Morganella morganii]
ATGAAAACATTAACATACAGTGAAGTGCGCCAAAATCTCACCGCTGCGATGAATGAAACAGTGGATGACCGTATCCCTAT
TTTAATCACACGGCAGAAAGGTACTGCATGCGTATTACTATCACTTGATGAATATCAGTCTCTGGAAGAGACCGCCTATC
TGATGCGTTCGCCGAATAACGCACGGCGTTTAATGGATTCCATTGACGAATTAAATGCCGGAAAGGGGCTCAAAAAGGAA
ATCAATGAATGA
ATGAAAACATTAACATACAGTGAAGTGCGCCAAAATCTCACCGCTGCGATGAATGAAACAGTGGATGACCGTATCCCTAT
TTTAATCACACGGCAGAAAGGTACTGCATGCGTATTACTATCACTTGATGAATATCAGTCTCTGGAAGAGACCGCCTATC
TGATGCGTTCGCCGAATAACGCACGGCGTTTAATGGATTCCATTGACGAATTAAATGCCGGAAAGGGGCTCAAAAAGGAA
ATCAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSE5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQE0 |