Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3845909..3846542 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag FOC59_RS17900 Protein ID WP_003403365.1
Coordinates 3845909..3846292 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag FOC59_RS17905 Protein ID WP_003403368.1
Coordinates 3846387..3846542 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17875 3841201..3841737 + 537 WP_003403341.1 50S ribosomal protein L10 -
FOC59_RS17880 3841774..3842166 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
FOC59_RS17885 3842159..3842854 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
FOC59_RS17890 3842925..3844430 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
FOC59_RS17895 3844511..3845521 + 1011 WP_031653722.1 ABC transporter ATP-binding protein -
FOC59_RS17900 3845909..3846292 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
FOC59_RS17905 3846387..3846542 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC59_RS17910 3846618..3847334 - 717 WP_003903122.1 CPBP family intramembrane metalloprotease -
FOC59_RS17915 3847610..3847918 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
FOC59_RS17920 3847905..3848150 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
FOC59_RS17925 3848260..3848697 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
FOC59_RS17930 3848694..3848948 - 255 WP_003911263.1 antitoxin VapB7 -
FOC59_RS17935 3849062..3851425 + 2364 WP_003403397.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T143930 WP_003403365.1 NZ_CP046308:c3846292-3845909 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T143930 NZ_CP061513:c485747-485424 [Morganella morganii]
ATGGATTACCTGGAATTTATCGAAACTAAAATTTTCAGCCATACCCGCAAAGAAATGATGACTGATGATGAATTCCGGGA
ATTTCAGAGCTATCTTTTGGAAAACTACGAACGGGGTAACACGATCAGTCAGACAGGCGGATGTAAGAAGATTCGCTGGC
AACGCAGGGGAACCGGTAAACAAGGCGGCCTCCGGGTCATTTATCACGCCCTTCCCGCTCACGGCAGATTGTACCTGCTT
CTTATCTACCCCAAAAATGTCAAAGATGATCTGAGTAGTCAGGAAAGAACGGTGCTCAGATCGTTATCACAGAAACTGAA
CTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT143930 WP_003403368.1 NZ_CP046308:c3846542-3846387 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT143930 NZ_CP061513:c485378-485073 [Morganella morganii]
ATGGATAAAACACTTTTTGAAAATCTGGTCAGCAGCATGGAAGAGATGGTGGCAATTGAAAAAGGCCACGTTGTTCCGGC
ACAGGAAAACAGGCACAGACACCCGATTCCGGATGTTAAAGCAATCCGCAAGCATGCCGGATTAAAACAGGCAGAATTTG
CAGATGCTATCGGTTCCAGTGTTGATCTGGTCCGCAGTTGGGAGCAGCATCGTCGTATTCCGTCAGGGATTGCCTTAAAA
ATGTTGTATCTCATTGAAAAACAACCCGCACTTTTATGTACACTACGATCAATCCCTCTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References