Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3810417..3811081 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag FOC59_RS17730 Protein ID WP_003403246.1
Coordinates 3810674..3811081 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag FOC59_RS17725 Protein ID WP_003403244.1
Coordinates 3810417..3810677 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17700 3806594..3807751 + 1158 WP_003903091.1 hypothetical protein -
FOC59_RS17705 3807762..3808709 + 948 WP_003403232.1 DUF732 domain-containing protein -
FOC59_RS17710 3808802..3809056 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
FOC59_RS17715 3809056..3809451 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
FOC59_RS17720 3809545..3810285 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FOC59_RS17725 3810417..3810677 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC59_RS17730 3810674..3811081 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS17735 3811153..3812304 - 1152 WP_003907440.1 FIST C-terminal domain-containing protein -
FOC59_RS17740 3812397..3814124 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T143929 WP_003403246.1 NZ_CP046308:3810674-3811081 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T143929 NZ_CP061498:c3389760-3389119 [Roseicitreum antarcticum]
ATGGCAAACAACTTGACCGCCGAAAAAGCTCTGATCTTCAGGATCACGCACATCAACAATGTGCCGTGGATCCTCAGGCA
TGGGCTTCATTGCAAGAACTCCGGTGTGCAGGATCCCCATTTTGTGCGAATTGGAAACCTCGAATTGATCCAGCGCCGGA
CAGCTCGAAACGTTCCTGTACCGCCTGGTGGGACGTTGTCGGATTATATCCCGTTCTACTTAACGCCATTCTCAATGATG
ATGTACAACATCAAGACTGGTTACGGAGGAATTCGTCAGTTTCCGAACAGGGAGATCGTTATCATGGCGTCGTCACTTCG
TGGGCTCGCGGATCGAAGCGTGGCAACCGTGTTCTCGGATCGTCATGCGTACCTCCAGACTGCGCAGTTCTTCACCTCGT
TAGACGACCTTGACAAGATCGACTGGGGCATCCTGCAACGTAGGGACTTCACACGCGACGTCGATGACCCCGAGAAGACG
GACCGCTACCAGGCAGAGGCGCTTGTACACAGGCACTTGCCAGTTGAGCACCTAGCAGGCATAGTGTGCTTGGGTGAGAA
CGAAAAAGGAACACTCGAACGGCAACGGGAGGAGGTTGGTCACGATCTCAAGATCGTGGCGCGACCGGGTTGGTATTTCT
GA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT143929 WP_003403244.1 NZ_CP046308:3810417-3810677 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT143929 NZ_CP061498:c3389119-3388040 [Roseicitreum antarcticum]
ATGGTAACTTACATGCAGGGCAATCTTCTTGAAGCTGACGTCGATGCGGTGGTGAACACTGTGAACACGGTAGGAATAAT
GGGCAAAGGAATTGCCCTGATGTTCAAGGAACAATTCCCAAGAAACTTCGAAGCCTACGCCCGTGCCTGCGATGCGGGCG
AAGTGCGTATTGGCAAAATGTTCGTTACCGAAAACAAGGAACTCTTCGGGCCGCGCTGGATCATCAATTTCCCGACTAAG
ACCCATTGGCGAGTCAAAACCAAGATCGAATGGGTCGAGGATGGATTGAAGGATCTTGTCCGAGTACTTCGAGAGAAGGA
AATTCATTCAATTGCAATTCCTCCACTCGGCTGCGGGAATGGCGGCCTCGACTGGAGCGATGTGCGTCCACTAATTGAGT
CGGCCTTGGCGGAACTTGATTGGGTCAATGTCAGCGTCTACGAGCCAACTTCCAAGTATCAGAATGTCGCCAAGCGCACC
GGTGTTGAGAAGCTCACCCCGGCACGCGCACTGGTGGCTGAGATGGTGCGTCGGTACTCACTCCTTGGGATCGAGTGCTC
AATTCTTGAGGTCCAGAAGCTGGGTTGGTTCCTCGAGCGCGGCATGACCCGGTTCGGAGGGTCGGATGCGCTCAAGTTCA
GGTTCCAAGCCAACAAGTACGGACCTTACTCGCATAACCTGACAAAACTGCTCGATAGCCTCGACGGCAGTTATCTCCGG
TGCGACAGACGCCTAGCTGATGCCGATCCCTTGGACCTCATTTGCTTCAACGACGCCAAATATGATCGAGTGCAAGCCTA
TCTGAACTCGGGTGAAGGGAAGCAGTTCTCAAGCGTACTGGAATGGGCTTCGGCAACCATCGATGGCTTCGAGTCGCCTC
TCGGCATGGAACTTCTGGCGACTGTCGACTGGATGATGCAGTACGACGATATCGAACCGACTGTTGAGGGAGTGATGGAA
GGTCTTAAGAGCTGGGCTGGTGGGGAAGCCGCTGGACAGCGCAAATTGAAGATCTTTGATCGCCGATTGGTCGCCATCGC
CTTGGGCCAACTTCAGACATCGAACAGGCTACCTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References