Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 3808802..3809451 | Replicon | chromosome |
| Accession | NZ_CP046308 | ||
| Organism | Mycobacterium tuberculosis strain FDAARGOS_751 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P67241 |
| Locus tag | FOC59_RS17715 | Protein ID | WP_003403236.1 |
| Coordinates | 3809056..3809451 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ34 |
| Locus tag | FOC59_RS17710 | Protein ID | WP_003403235.1 |
| Coordinates | 3808802..3809056 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FOC59_RS21120 | 3803927..3804010 | + | 84 | Protein_3462 | galactose-1-phosphate uridylyltransferase | - |
| FOC59_RS17690 | 3804029..3805111 | + | 1083 | WP_031652152.1 | galactose-1-phosphate uridylyltransferase | - |
| FOC59_RS17695 | 3805108..3806199 | + | 1092 | WP_003900977.1 | galactokinase | - |
| FOC59_RS17700 | 3806594..3807751 | + | 1158 | WP_003903091.1 | hypothetical protein | - |
| FOC59_RS17705 | 3807762..3808709 | + | 948 | WP_003403232.1 | DUF732 domain-containing protein | - |
| FOC59_RS17710 | 3808802..3809056 | + | 255 | WP_003403235.1 | type II toxin-antitoxin system antitoxin VapB30 | Antitoxin |
| FOC59_RS17715 | 3809056..3809451 | + | 396 | WP_003403236.1 | type II toxin-antitoxin system toxin ribonuclease C30 | Toxin |
| FOC59_RS17720 | 3809545..3810285 | - | 741 | WP_003403239.1 | TVP38/TMEM64 family protein | - |
| FOC59_RS17725 | 3810417..3810677 | + | 261 | WP_003403244.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FOC59_RS17730 | 3810674..3811081 | + | 408 | WP_003403246.1 | type II toxin-antitoxin system VapC family toxin | - |
| FOC59_RS17735 | 3811153..3812304 | - | 1152 | WP_003907440.1 | FIST C-terminal domain-containing protein | - |
| FOC59_RS17740 | 3812397..3814124 | - | 1728 | WP_003900979.1 | exodeoxyribonuclease V subunit alpha | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14250.04 Da Isoelectric Point: 4.7475
>T143928 WP_003403236.1 NZ_CP046308:3809056-3809451 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP
Download Length: 396 bp
>T143928 NZ_CP061498:c2243640-2243122 [Roseicitreum antarcticum]
ATGAGCGGCGATAGTGTGCCCGCCCAAGCGCCCCTTGTCGTTAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGCCTGATCGAAGAGGTTGAGGCGCGCAAAGCGCGTGATCCCAAGAGCTGGCGCAAGAAAAACTGCACGA
AGCGGCTGGCCGCCATCTTCAAGCTGGTGACGGAGGCCATACCGGCGGATCCGGGTGCCGCGGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCAAAGTTCTTTCAACAGTATCGGTTGTTCTACCGGTTCAACAGCGA
TGCGAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACCCTGCGCGCTTACGGCAGCAAGACGGATGCCTATGCGA
CCTTCAAAGGGATGTTGGACAATGGCAACCCACCTGACAATTTCGACGCGCTCTTGAAAGAAGCTGCGGCAGCGGACAAG
CGGTTCGAAGCTTCCCTTGAAGCGGTGCCTGATCGGTAA
ATGAGCGGCGATAGTGTGCCCGCCCAAGCGCCCCTTGTCGTTAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGCCTGATCGAAGAGGTTGAGGCGCGCAAAGCGCGTGATCCCAAGAGCTGGCGCAAGAAAAACTGCACGA
AGCGGCTGGCCGCCATCTTCAAGCTGGTGACGGAGGCCATACCGGCGGATCCGGGTGCCGCGGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCAAAGTTCTTTCAACAGTATCGGTTGTTCTACCGGTTCAACAGCGA
TGCGAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACCCTGCGCGCTTACGGCAGCAAGACGGATGCCTATGCGA
CCTTCAAAGGGATGTTGGACAATGGCAACCCACCTGACAATTTCGACGCGCTCTTGAAAGAAGCTGCGGCAGCGGACAAG
CGGTTCGAAGCTTCCCTTGAAGCGGTGCCTGATCGGTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9139.52 Da Isoelectric Point: 9.2702
>AT143928 WP_003403235.1 NZ_CP046308:3808802-3809056 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA
Download Length: 255 bp
>AT143928 NZ_CP061498:c2243963-2243637 [Roseicitreum antarcticum]
ATGACAGCGCTCGCACAAGATGTATCGAAACTCACTGATCGGTATCAGACGACCGTTCCGGCCGGTGTGCGCAAGCAGCT
CAAGCTGGGCAAGGGCGACCAGATTCGCTACTGCACCGAACCGAGTGGCAGGGTCTATATCGAGCCCGTGCGCGCCGAAG
AGGAAGATCCTGTTCTCGGAGCCTTTCTCGATTTTGTCGAAGCCGATATCAAGGCGCATCCGGACCGCATTCGGGCGTTC
GATGGGGCTTTGCATGACCGTCTTGCAGCACTGGTCGGAGACGTTGACGTCGATCTCGATGCGCCGCTATCGCTCGAGGA
TGAATGA
ATGACAGCGCTCGCACAAGATGTATCGAAACTCACTGATCGGTATCAGACGACCGTTCCGGCCGGTGTGCGCAAGCAGCT
CAAGCTGGGCAAGGGCGACCAGATTCGCTACTGCACCGAACCGAGTGGCAGGGTCTATATCGAGCCCGTGCGCGCCGAAG
AGGAAGATCCTGTTCTCGGAGCCTTTCTCGATTTTGTCGAAGCCGATATCAAGGCGCATCCGGACCGCATTCGGGCGTTC
GATGGGGCTTTGCATGACCGTCTTGCAGCACTGGTCGGAGACGTTGACGTCGATCTCGATGCGCCGCTATCGCTCGAGGA
TGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4XGR | |
| PDB | 4XGQ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSC2 |