Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3808802..3809451 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag FOC59_RS17715 Protein ID WP_003403236.1
Coordinates 3809056..3809451 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag FOC59_RS17710 Protein ID WP_003403235.1
Coordinates 3808802..3809056 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS21120 3803927..3804010 + 84 Protein_3462 galactose-1-phosphate uridylyltransferase -
FOC59_RS17690 3804029..3805111 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FOC59_RS17695 3805108..3806199 + 1092 WP_003900977.1 galactokinase -
FOC59_RS17700 3806594..3807751 + 1158 WP_003903091.1 hypothetical protein -
FOC59_RS17705 3807762..3808709 + 948 WP_003403232.1 DUF732 domain-containing protein -
FOC59_RS17710 3808802..3809056 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
FOC59_RS17715 3809056..3809451 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
FOC59_RS17720 3809545..3810285 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
FOC59_RS17725 3810417..3810677 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC59_RS17730 3810674..3811081 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
FOC59_RS17735 3811153..3812304 - 1152 WP_003907440.1 FIST C-terminal domain-containing protein -
FOC59_RS17740 3812397..3814124 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T143928 WP_003403236.1 NZ_CP046308:3809056-3809451 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T143928 NZ_CP061498:c2243640-2243122 [Roseicitreum antarcticum]
ATGAGCGGCGATAGTGTGCCCGCCCAAGCGCCCCTTGTCGTTAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGCCTGATCGAAGAGGTTGAGGCGCGCAAAGCGCGTGATCCCAAGAGCTGGCGCAAGAAAAACTGCACGA
AGCGGCTGGCCGCCATCTTCAAGCTGGTGACGGAGGCCATACCGGCGGATCCGGGTGCCGCGGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCAAAGTTCTTTCAACAGTATCGGTTGTTCTACCGGTTCAACAGCGA
TGCGAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACCCTGCGCGCTTACGGCAGCAAGACGGATGCCTATGCGA
CCTTCAAAGGGATGTTGGACAATGGCAACCCACCTGACAATTTCGACGCGCTCTTGAAAGAAGCTGCGGCAGCGGACAAG
CGGTTCGAAGCTTCCCTTGAAGCGGTGCCTGATCGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT143928 WP_003403235.1 NZ_CP046308:3808802-3809056 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT143928 NZ_CP061498:c2243963-2243637 [Roseicitreum antarcticum]
ATGACAGCGCTCGCACAAGATGTATCGAAACTCACTGATCGGTATCAGACGACCGTTCCGGCCGGTGTGCGCAAGCAGCT
CAAGCTGGGCAAGGGCGACCAGATTCGCTACTGCACCGAACCGAGTGGCAGGGTCTATATCGAGCCCGTGCGCGCCGAAG
AGGAAGATCCTGTTCTCGGAGCCTTTCTCGATTTTGTCGAAGCCGATATCAAGGCGCATCCGGACCGCATTCGGGCGTTC
GATGGGGCTTTGCATGACCGTCTTGCAGCACTGGTCGGAGACGTTGACGTCGATCTCGATGCGCCGCTATCGCTCGAGGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References