Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3803173..3803798 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FOC59_RS17685 Protein ID WP_003403218.1
Coordinates 3803397..3803798 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FOC59_RS17680 Protein ID WP_003403213.1
Coordinates 3803173..3803400 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17650 3798352..3798573 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FOC59_RS17655 3798715..3799320 + 606 WP_003898526.1 hypothetical protein -
FOC59_RS17660 3799339..3801906 - 2568 WP_003900188.1 SEC-C domain-containing protein -
FOC59_RS17665 3801990..3802739 + 750 WP_003898528.1 hypothetical protein -
FOC59_RS17670 3802736..3802978 + 243 WP_003403210.1 hypothetical protein -
FOC59_RS17680 3803173..3803400 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FOC59_RS17685 3803397..3803798 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FOC59_RS21120 3803927..3804010 + 84 Protein_3462 galactose-1-phosphate uridylyltransferase -
FOC59_RS17690 3804029..3805111 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
FOC59_RS17695 3805108..3806199 + 1092 WP_003900977.1 galactokinase -
FOC59_RS17700 3806594..3807751 + 1158 WP_003903091.1 hypothetical protein -
FOC59_RS17705 3807762..3808709 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T143927 WP_003403218.1 NZ_CP046308:3803397-3803798 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T143927 NZ_CP061497:c2966614-2965331 [Thermomonas sp. XSG]
ATGAAACACGTCGACGTCATCGAGGTGCGGATCTGGGGCAAGCAGGTCGGCGCCGTGGCGCAGGACCCGCGCTTGGGCGC
GTATGTGTTCGAGTACGCCGACAGCTGGCGCCGCACCGGTATCGCGCTGTCGCCTTTCATGCTGCCGCTGGATCGGGCCG
ATGGCCGCTTCGCCTTTCCCGCGCTGGACCCCGACGCCTTCCATCGCCTGCCCGGCCTGCTTGCCGACGCACTGCCCGAC
GATTTCGGCAACCAGCTGATCAACGGCTGGATGGCCAGCCACGGCATCCGCCCGGAGGAAGTGACCGCACTGGACCGGCT
GGCCTACATGGGCCGGCGCGGGATGGGCGCGCTGGAGTTCCGCCCCACCCGCGGCGGCAACACGGAAACCGCAGCCCCGA
TCGAGATGAAGGCGCTGGTGGAGGTGGCGCGCAAAGCGGTGCACGGCGCCCTGGCCGGCGACCCGGAGGCGCAGGCGGCG
CTGGCCAGCATCATCCGCGTGGGAACCTCCGCCGGCGGTGCCCGCGCCAAGGCCGTGGTGGCGTGGAACCCGGCCACCGA
TGAGCTGCGCAGCGGCCAGTTCGACGCCGCGCCGGGCTTCGAGCACTGGCTGCTGAAGTTCGACGGGATGGGCGCGGACC
AGGAACTGGGCCAGAGCCAGTGCTACGGCCGGCGCGAGTACGCCTACCACCTGATGGCCACCGCCGCCGGCATCACCATG
AGCGCGTGCCGGCTGCTGGAGGAGAACGGCCGCGCCCACTTCATGACGCGCCGGTTCGACCGCGACGGCAACCGCAAGAT
CCACATGCAGACGCTGGCCGCGCTGCAGCACATGAGCCACAGGCAGCGGCGCACCCACGCCTACGAATCCCTGTTCATCA
CCGCCCACGGACTGGGCCTGCCCGAACGCGACATGGAGCAGCTGTTCCTGCGCATGGCGTTCAACGTCGCCAGCAAGAAC
CATGACGACCACACCAAGAACTTCGCCTTCCTGCTGCGCGAAGGCGGCGCGTGGGCGCTGGCGCCCGCTTACGACGTAAC
CCACGCCTACAACCCTGCCGGCGAATGGACGCAGCACCACCTGATGAGCGTGGCCGGCAAGTTCGACGACATCACCGCCG
ACGACCTGCGCGAGGTCGCCGCGCGCTTCAGCATCCGCAACCCGTCCACGCTGATGGACCAGGTGGACGCGGCTATCGCG
CGCTGGCCCGAGTTTGCACAGGTGGCCGGACTGCCCGCCTCGGATCGCGACGATGTCGGCAGGCTGCTGATCCGGTTGCG
CTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT143927 WP_003403213.1 NZ_CP046308:3803173-3803400 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT143927 NZ_CP061497:c2966920-2966621 [Thermomonas sp. XSG]
ATGGCTACACCATCCTTCCAAACCCCCGAAGAGATCCAAACGGATCTGGGCCAGCGGCTGCGCCAGCTCCGGCTCGGCCA
GCGGTTGACCCAGGCCGGGTTGGCCACCCGGGCCGGCGTCTCGCCGCGCGCCCTGCGCGGGCTGGAGAGCGGAGAAGGTT
CCTCCCTGATCACCCTGATCCGCGTGCTCAAGGCCCTCGGCGCGCTGACCAGCCTGGACGCGCTGGCGCCGCAACCCACG
ATCAGCCCGATGGCCCTGCTCGCCGGCAACCGCGCGCCCAAGCGCGGCACCCGCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References