Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3795635..3796278 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag FOC59_RS17625 Protein ID WP_003403187.1
Coordinates 3795877..3796278 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag FOC59_RS17620 Protein ID WP_003403184.1
Coordinates 3795635..3795880 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17585 3790915..3791445 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FOC59_RS17590 3791429..3792124 - 696 WP_003918099.1 two-component system response regulator TcrA -
FOC59_RS17595 3792247..3792558 + 312 WP_003403164.1 hypothetical protein -
FOC59_RS17600 3792630..3793580 + 951 WP_003907436.1 DUF1259 domain-containing protein -
FOC59_RS17605 3793821..3794405 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FOC59_RS17610 3794407..3795117 + 711 Protein_3448 transposase -
FOC59_RS17615 3795120..3795590 + 471 WP_003898523.1 hypothetical protein -
FOC59_RS17620 3795635..3795880 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FOC59_RS17625 3795877..3796278 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS17635 3796666..3796833 - 168 WP_077385191.1 DUF3800 domain-containing protein -
FOC59_RS17640 3796866..3797063 - 198 WP_003403191.1 hypothetical protein -
FOC59_RS17645 3797386..3798300 - 915 WP_003908555.1 hypothetical protein -
FOC59_RS17650 3798352..3798573 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FOC59_RS17655 3798715..3799320 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T143926 WP_003403187.1 NZ_CP046308:3795877-3796278 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T143926 NZ_CP061497:c1325730-1325578 [Thermomonas sp. XSG]
ATGAAGCGCTTGATCGCCCTGCTGATGCTGGTCATGTTCTCCAGCATGGTCCTGACCGCCTGCAACACCGTTGCCGGCGC
GGGCAAGGATGTACAGAAGGCCGGTGAAAAGGTCGAAGAAAAGGCCCAGGACTGCAAGGACATGAAGTGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT143926 WP_003403184.1 NZ_CP046308:3795635-3795880 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT143926 NZ_CP061497:c1325462-1325334 [Thermomonas sp. XSG]
ATGAAGCAGATGAAGATGGCCCTGGTGGCGTTGGCCTGCCTGGCTTTCCTGGCTGGCTGCAACACCATTGCCGGTGCAGG
CAAGGATATCCAGAAGGCCGGCGAGAAGATCGAGGGCGCGGTCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References