Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 3789545..3790191 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag FOC59_RS17570 Protein ID WP_003403137.1
Coordinates 3789545..3789958 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag FOC59_RS17575 Protein ID WP_003403139.1
Coordinates 3789955..3790191 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T143925 WP_003403137.1 NZ_CP046308:c3789958-3789545 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T143925 NZ_CP061497:c1325462-1325334 [Thermomonas sp. XSG]
ATGAAGCAGATGAAGATGGCCCTGGTGGCGTTGGCCTGCCTGGCTTTCCTGGCTGGCTGCAACACCATTGCCGGTGCAGG
CAAGGATATCCAGAAGGCCGGCGAGAAGATCGAGGGCGCGGTCAAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT143925 WP_003403139.1 NZ_CP046308:c3790191-3789955 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT143925 NZ_CP061497:c1325730-1325578 [Thermomonas sp. XSG]
ATGAAGCGCTTGATCGCCCTGCTGATGCTGGTCATGTTCTCCAGCATGGTCCTGACCGCCTGCAACACCGTTGCCGGCGC
GGGCAAGGATGTACAGAAGGCCGGTGAAAAGGTCGAAGAAAAGGCCCAGGACTGCAAGGACATGAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References