143925

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 3789545..3790191 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag FOC59_RS17570 Protein ID WP_003403137.1
Coordinates 3789545..3789958 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag FOC59_RS17575 Protein ID WP_003403139.1
Coordinates 3789955..3790191 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17550 3785628..3787178 + 1551 WP_003403119.1 MCE family protein -
FOC59_RS17555 3787230..3787622 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
FOC59_RS17560 3787619..3787876 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
FOC59_RS17565 3788059..3789294 - 1236 WP_003403128.1 ATP-binding protein -
FOC59_RS17570 3789545..3789958 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS17575 3789955..3790191 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FOC59_RS17580 3790295..3790801 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FOC59_RS17585 3790915..3791445 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FOC59_RS17590 3791429..3792124 - 696 WP_003918099.1 two-component system response regulator TcrA -
FOC59_RS17595 3792247..3792558 + 312 WP_003403164.1 hypothetical protein -
FOC59_RS17600 3792630..3793580 + 951 WP_003907436.1 DUF1259 domain-containing protein -
FOC59_RS17605 3793821..3794405 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
FOC59_RS17610 3794407..3795117 + 711 Protein_3448 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T143925 WP_003403137.1 NZ_CP046308:c3789958-3789545 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T143925 NZ_CP061497:c1325462-1325334 [Thermomonas sp. XSG]
ATGAAGCAGATGAAGATGGCCCTGGTGGCGTTGGCCTGCCTGGCTTTCCTGGCTGGCTGCAACACCATTGCCGGTGCAGG
CAAGGATATCCAGAAGGCCGGCGAGAAGATCGAGGGCGCGGTCAAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT143925 WP_003403139.1 NZ_CP046308:c3790191-3789955 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT143925 NZ_CP061497:c1325730-1325578 [Thermomonas sp. XSG]
ATGAAGCGCTTGATCGCCCTGCTGATGCTGGTCATGTTCTCCAGCATGGTCCTGACCGCCTGCAACACCGTTGCCGGCGC
GGGCAAGGATGTACAGAAGGCCGGTGAAAAGGTCGAAGAAAAGGCCCAGGACTGCAAGGACATGAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References