143924

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3787230..3787876 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag FOC59_RS17555 Protein ID WP_003403122.1
Coordinates 3787230..3787622 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag FOC59_RS17560 Protein ID WP_003403125.1
Coordinates 3787619..3787876 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS17540 3782892..3784418 + 1527 WP_003403112.1 virulence factor Mce family protein -
FOC59_RS17545 3784481..3785623 + 1143 WP_003911253.1 virulence factor Mce family protein -
FOC59_RS17550 3785628..3787178 + 1551 WP_003403119.1 MCE family protein -
FOC59_RS17555 3787230..3787622 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
FOC59_RS17560 3787619..3787876 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
FOC59_RS17565 3788059..3789294 - 1236 WP_003403128.1 ATP-binding protein -
FOC59_RS17570 3789545..3789958 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
FOC59_RS17575 3789955..3790191 - 237 WP_003403139.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FOC59_RS17580 3790295..3790801 - 507 WP_003900973.1 two component system sensor kinase HK1 -
FOC59_RS17585 3790915..3791445 - 531 WP_003917320.1 two component system sensor kinase HK2 -
FOC59_RS17590 3791429..3792124 - 696 WP_003918099.1 two-component system response regulator TcrA -
FOC59_RS17595 3792247..3792558 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T143924 WP_003403122.1 NZ_CP046308:c3787622-3787230 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T143924 NZ_CP061474:c3181844-3181494 [Geobacillus sp. 46C-IIa]
TTGATTGTCAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTCGTTGGCTCAGAGCAGGGCGGCGTACGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGCTTCAGTCCGACGGTAATTGTCGCGGCGATTACGGCGCAAATCCAAAAGG
CGAAACTGCCGACGCACGTCGAAATTGATGCGAAACGCTACGGGTTTGAGCGCGATTCGGTCATTTTGCTTGAGCAAATT
CGTACGATTGATAAACAACGGTTGACCGATAAAATTACCCACTTGGATGATGAAATGATGGATAAGGTCGATGAGGCGCT
GCAAATCAGCTTGGGTTTGATCGACTTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT143924 WP_003403125.1 NZ_CP046308:c3787876-3787619 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT143924 NZ_CP061474:c3182130-3181849 [Geobacillus sp. 46C-IIa]
GTGTCGGAATCTGGCGCAACAACGGAAATCATCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGGGCTCGTAAA
GCAGGAGAATGGCAATCGCAATGAACTCATTTATCAGGCGACGAAAATGTATATTCGCGAGCGAAAAAAACGGCAAATTC
GCGAGGCGATGAGACGAGGCTACATGGAAATGGCCAAAATCAATTTATCTATTGCTTCTGAAGCGTTTCATGCTGAATAT
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References