Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3455616..3456259 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag FOC59_RS16040 Protein ID WP_003401566.1
Coordinates 3455834..3456259 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag FOC59_RS16035 Protein ID WP_003401563.1
Coordinates 3455616..3455837 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS16010 3450864..3451667 - 804 WP_003401540.1 hypothetical protein -
FOC59_RS16015 3451677..3453074 - 1398 WP_003401544.1 sulfatase -
FOC59_RS16020 3453253..3454899 + 1647 WP_031654185.1 PE family protein -
FOC59_RS16025 3455042..3455269 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
FOC59_RS16030 3455266..3455568 + 303 WP_003401560.1 toxin-antitoxin system toxin -
FOC59_RS16035 3455616..3455837 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
FOC59_RS16040 3455834..3456259 + 426 WP_003401566.1 PIN domain nuclease Toxin
FOC59_RS16045 3456395..3457027 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
FOC59_RS16050 3457024..3457932 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T143920 WP_003401566.1 NZ_CP046308:3455834-3456259 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T143920 NZ_CP061472:c462686-462267 [Geobacillus thermoleovorans]
ATGAAAAGTGATGTCATTTTAAACAAGATCAGCGTGATCGAACGCTGCCTGAAACGAATTCGTGAAGAATATAACGGCGA
TCCAAAAAATTTACAAAATTACACAAAACAAGATTCGATCGTTCTGAATTTACAGCGGGCGTGCGAGGCATGCATCGATT
TGGCCATGCATATTGTGGCCGAGCAGAAATTCGGATTGCCGCAGCATAGCCGCGATGCATTCGCTCTCCTCGAAGAACAT
GGGGTCATCTCCCCTTCCATAAGCAAAAAGATGAAGGCGATGGTCGGATTCCGCAACATCGCCGTTCACGACTATCAACA
ACTGAACCTTGGCATCTTGCAAGCCATCGTCGAACACCATCTTGATGATTTCAAACAATTTACGAAAGCCATCCTCGATT
ATGCTAAGAAAAACAGCTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT143920 WP_003401563.1 NZ_CP046308:3455616-3455837 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT143920 NZ_CP061472:c463083-462676 [Geobacillus thermoleovorans]
TTGCCAAACGAAATGGAGACGATCATCATTCAGACGCTCCGCCCGGCTCTTCACCCGTTCGTCATCTACCTGTTCGGTTC
AGCCGCCCGTGGGACGCTGCGCCCAGACAGCGATGTCGACATCGCCTTTGTCAGCGACGGCGAACCGCATGATCCGTATG
AGCTGTTTCGGCTCGCCGGGGAGTTGGCTGACAAGTTAGGGCGAGATGTCGATCTTGTCGATTTGCGCCAAGCCAGCACC
GTGTTTCAAGCGCAAGTCGTCTCGACGGGAAAAGCCATTGATTGCCGCGACGAGCGGAAACGGGCTGAGTTCGAAATGAA
AACATTGAAAATGTATGTGAAACTAAACGAAGAGAGAGCACCGGTGTTAAAACAAATTACGGAAAGCGGGAGCATATATG
AAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References