Detailed information of TA system TA143918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 3455042..3455568
• Replicon: chromosome
• Accession: NZ_CP046308
• Organism: Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: FOC59_RS16030
• Protein ID: WP_003401560.1
• Coordinates: 3455266..3455568 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: FOC59_RS16025
• Protein ID: WP_003401555.1
• Coordinates: 3455042..3455269 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC59_RS16005	3450090..3450875	+	786	WP_003401538.1	trans-aconitate 2-methyltransferase	-
FOC59_RS16010	3450864..3451667	-	804	WP_003401540.1	hypothetical protein	-
FOC59_RS16015	3451677..3453074	-	1398	WP_003401544.1	sulfatase	-
FOC59_RS16020	3453253..3454899	+	1647	WP_031654185.1	PE family protein	-
FOC59_RS16025	3455042..3455269	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
FOC59_RS16030	3455266..3455568	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
FOC59_RS16035	3455616..3455837	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
FOC59_RS16040	3455834..3456259	+	426	WP_003401566.1	PIN domain nuclease	-
FOC59_RS16045	3456395..3457027	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
FOC59_RS16050	3457024..3457932	+	909	WP_003900117.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T143918 WP_003401560.1 NZ_CP046308:3455266-3455568 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T143918 NZ_CP061471:2420529-2420879 [Geobacillus zalihae]
TTGATTGTCAAACGTGGCGACGTGTATTTTGCGGACCTTTCCCCGGTTGTTGGCTCGGAGCAGGGCGGCGTGCGCCCCGT
GTTGGTGATCCAAAACGATATCGGCAATCGTTTTAGCCCGACGGTGATTGTCGCGGCGATTACGGCGCAAATCCAAAAAG
CGAAGCTGCCGACGCATGTCGAGATTGACGCGAAACGCTACGGGTTTGAACGCGATTCGGTCATTTTGCTTGAGCAAATT
CGCACGATCGACAAGCAACGGCTGACCGATAAAATCACTCATTTGGACGATGAAATGATGGATAAAGTCGATGAGGCGCT
GCAAATTAGCTTAGGGCTGATCGACTTTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT143918 WP_003401555.1 NZ_CP046308:3455042-3455269 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT143918 NZ_CP061471:2420243-2420524 [Geobacillus zalihae]
GTGTCGGAATCTGGCGCAACAGCGGAAATCGTCGTTCGTTTGCCGCAGTCGCTGCTGACAGAACTGGACGTGCTCGTAAA
GCAGGAAAACGGCAACCGCAATGAACTCATTTATCAAGCGACGAAAATGTACATTCGCGAGCGGAAGAAACGGCAAATTC
GTGAGGCGATGAGACGAGGCTACATGGAAATGGCGAAAATCAATTTATCTATCGCTTCTGAAGCGTTTCATGCTGAATAC
GAGGCCGACCACACCGTTGAACGCTTAGTTAGCGGGGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1