Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2383633..2384307 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FOC59_RS11280 Protein ID WP_003417282.1
Coordinates 2383633..2384061 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FOC59_RS11285 Protein ID WP_003417286.1
Coordinates 2384065..2384307 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS11255 2379455..2379856 - 402 WP_003417264.1 cytidine deaminase -
FOC59_RS11260 2379997..2380431 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
FOC59_RS11265 2380428..2380862 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FOC59_RS11270 2380991..2382763 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FOC59_RS11275 2382763..2383554 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FOC59_RS11280 2383633..2384061 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS11285 2384065..2384307 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FOC59_RS11290 2384429..2385043 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FOC59_RS11295 2385040..2385705 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FOC59_RS11300 2385706..2386239 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FOC59_RS11305 2386236..2386610 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FOC59_RS11310 2386707..2387354 - 648 Protein_2215 cyclic pyranopterin phosphate synthase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T143913 WP_003417282.1 NZ_CP046308:c2384061-2383633 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T143913 NZ_CP061407:c19053-18703 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT143913 WP_003417286.1 NZ_CP046308:c2384307-2384065 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT143913 NZ_CP061407:c18698-18396 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References