Detailed information of TA system TA143913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2383633..2384307
• Replicon: chromosome
• Accession: NZ_CP046308
• Organism: Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF52
• Locus tag: FOC59_RS11280
• Protein ID: WP_003417282.1
• Coordinates: 2383633..2384061 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TI59
• Locus tag: FOC59_RS11285
• Protein ID: WP_003417286.1
• Coordinates: 2384065..2384307 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC59_RS11255	2379455..2379856	-	402	WP_003417264.1	cytidine deaminase	-
FOC59_RS11260	2379997..2380431	+	435	WP_072460198.1	succinate dehydrogenase, cytochrome b556 subunit	-
FOC59_RS11265	2380428..2380862	+	435	WP_003417269.1	succinate dehydrogenase hydrophobic membrane anchor subunit	-
FOC59_RS11270	2380991..2382763	+	1773	WP_003417273.1	succinate dehydrogenase flavoprotein subunit	-
FOC59_RS11275	2382763..2383554	+	792	WP_003417279.1	succinate dehydrogenase iron-sulfur subunit	-
FOC59_RS11280	2383633..2384061	-	429	WP_003417282.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC59_RS11285	2384065..2384307	-	243	WP_003417286.1	ribbon-helix-helix domain-containing protein	Antitoxin
FOC59_RS11290	2384429..2385043	-	615	WP_003417288.1	class I SAM-dependent methyltransferase	-
FOC59_RS11295	2385040..2385705	-	666	WP_003417290.1	molybdopterin converting factor subunit 1	-
FOC59_RS11300	2385706..2386239	-	534	WP_003417293.1	cyclic pyranopterin monophosphate synthase MoaC	-
FOC59_RS11305	2386236..2386610	-	375	WP_003417295.1	4a-hydroxytetrahydrobiopterin dehydratase	-
FOC59_RS11310	2386707..2387354	-	648	Protein_2215	cyclic pyranopterin phosphate synthase MoaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-141)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15834.16 Da
• Isoelectric Point: 8.5471

>T143913 WP_003417282.1 NZ_CP046308:c2384061-2383633 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Nucleotide

• Length: 429 bp

>T143913 NZ_CP061407:c19053-18703 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8849.86 Da
• Isoelectric Point: 5.1007

>AT143913 WP_003417286.1 NZ_CP046308:c2384307-2384065 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Nucleotide

• Length: 243 bp

>AT143913 NZ_CP061407:c18698-18396 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Structures

Toxin

• AlphaFold DB: A0A7U4FBL0

Antitoxin

• AlphaFold DB: G0TI59