Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1857219..1857906 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag FOC59_RS08870 Protein ID WP_003414624.1
Coordinates 1857463..1857906 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag FOC59_RS08865 Protein ID WP_003414620.1
Coordinates 1857219..1857476 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS08845 1852539..1853393 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
FOC59_RS08850 1853449..1854612 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
FOC59_RS08855 1854629..1855843 - 1215 WP_003414610.1 zinc metalloprotease Rip -
FOC59_RS08860 1855851..1857092 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
FOC59_RS08865 1857219..1857476 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
FOC59_RS08870 1857463..1857906 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS08875 1857986..1858648 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
FOC59_RS08880 1858744..1858935 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC59_RS08885 1859267..1861015 + 1749 WP_003912869.1 cytochrome c biogenesis protein DipZ -
FOC59_RS08890 1861111..1861692 + 582 WP_003414644.1 fasciclin domain-containing protein -
FOC59_RS08895 1861792..1862058 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T143911 WP_003414624.1 NZ_CP046308:1857463-1857906 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T143911 NZ_CP061406:c3159-2872 [Klebsiella pneumoniae]
ATGACATATACCGTCAAATTCAGGGAAGATGCGCTAAAAGAATGGAACAAGCTGGATAAGACTATTCAGCAGCAGTTTGC
AAAGAAACTTAAAAAGTGCTGTGAAAACCCACACATTCCTTCAGCAAAACTACGTGGTATAAAGGATTGCTATAAAATAA
AACTGCGAGCATCTGGTTTTCGCCTCGTCTATCAGGTCATAGATAATCAACTTATAATTGCTATTGTGGCTGTAGGCAAA
CGGGAGCGAAGTGACGTTTATACACTGGCGAGTGAACGTATGAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT143911 WP_003414620.1 NZ_CP046308:1857219-1857476 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT143911 NZ_CP061406:c3407-3156 [Klebsiella pneumoniae]
ATGCCACATATCATTCTGAGTGACACGACTGCCAGCGTCAGTGAATTGAAAAAAAACCCGATGGCCACAGTCAGCGCCGG
TGACGGGTTCCCAGTAGCGATTCTTAACCGGAACCAGCCAGCTTTCTATTGCGTGCCTGCGGAACTCTACGAAAAGATGC
TTGATGCGCTGGATGATCAGGAACTCATTAAACTGGTTGCAGAACGCAGTAATCAACCGCTGTTTGATGTGGACCTGGAT
AAGTACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References