Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 1810702..1811306 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag FOC59_RS08635 Protein ID WP_003414492.1
Coordinates 1810702..1811094 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag FOC59_RS08640 Protein ID WP_003414495.1
Coordinates 1811091..1811306 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS08605 1805852..1806640 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
FOC59_RS08610 1806974..1807519 - 546 WP_003904931.1 DUF1802 family protein -
FOC59_RS08615 1807791..1808675 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FOC59_RS08620 1808678..1809565 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
FOC59_RS08625 1809870..1810415 - 546 WP_003908074.1 DUF1802 family protein -
FOC59_RS08630 1810412..1810681 - 270 WP_003414489.1 DUF2277 family protein -
FOC59_RS08635 1810702..1811094 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC59_RS08640 1811091..1811306 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC59_RS08645 1811353..1812102 + 750 WP_003908075.1 enoyl-CoA hydratase -
FOC59_RS08650 1812181..1813263 - 1083 WP_003908076.1 ABC transporter ATP-binding protein -
FOC59_RS08655 1813256..1814566 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
FOC59_RS08660 1814569..1815396 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
FOC59_RS08665 1815393..1816304 - 912 WP_003904073.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T143909 WP_003414492.1 NZ_CP046308:c1811094-1810702 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T143909 NZ_CP061404:c5358207-5357824 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT143909 WP_003414495.1 NZ_CP046308:c1811306-1811091 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT143909 NZ_CP061404:c5358449-5358207 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References