Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1544969..1545606 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag FOC59_RS07180 Protein ID WP_003413180.1
Coordinates 1544969..1545364 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag FOC59_RS07185 Protein ID WP_003413183.1
Coordinates 1545361..1545606 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS07140 1540372..1541583 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
FOC59_RS07145 1541710..1542369 + 660 WP_003900846.1 LppA family lipoprotein -
FOC59_RS07150 1542366..1543028 + 663 WP_003903936.1 hypothetical protein -
FOC59_RS07155 1543025..1543303 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
FOC59_RS07160 1543396..1543809 + 414 WP_003413164.1 PIN domain nuclease -
FOC59_RS07165 1543848..1544105 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
FOC59_RS07170 1544102..1544479 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
FOC59_RS07175 1544495..1544869 - 375 WP_003413177.1 hypothetical protein -
FOC59_RS07180 1544969..1545364 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
FOC59_RS07185 1545361..1545606 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
FOC59_RS07190 1546017..1546436 - 420 WP_003413190.1 A24 family peptidase -
FOC59_RS07195 1546448..1547257 - 810 WP_003413193.1 shikimate dehydrogenase -
FOC59_RS07200 1547254..1548510 - 1257 WP_014585306.1 endolytic transglycosylase MltG -
FOC59_RS07205 1548503..1549015 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T143902 WP_003413180.1 NZ_CP046308:c1545364-1544969 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T143902 NZ_CP061404:836009-836419 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT143902 WP_003413183.1 NZ_CP046308:c1545606-1545361 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT143902 NZ_CP061404:835762-836028 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References