Detailed information of TA system TA143900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1543396..1544105
• Replicon: chromosome
• Accession: NZ_CP046308
• Organism: Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ26
• Locus tag: FOC59_RS07160
• Protein ID: WP_003413164.1
• Coordinates: 1543396..1543809 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P95006
• Locus tag: FOC59_RS07165
• Protein ID: WP_003413167.1
• Coordinates: 1543848..1544105 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC59_RS07130	1538449..1539654	-	1206	WP_003413027.1	chorismate synthase	-
FOC59_RS07135	1539762..1540076	+	315	WP_009937839.1	hypothetical protein	-
FOC59_RS07140	1540372..1541583	+	1212	WP_003900845.1	alpha/beta hydrolase family protein	-
FOC59_RS07145	1541710..1542369	+	660	WP_003900846.1	LppA family lipoprotein	-
FOC59_RS07150	1542366..1543028	+	663	WP_003903936.1	hypothetical protein	-
FOC59_RS07155	1543025..1543303	+	279	WP_003901422.1	type II toxin-antitoxin system VapB family antitoxin	-
FOC59_RS07160	1543396..1543809	+	414	WP_003413164.1	PIN domain nuclease	Toxin
FOC59_RS07165	1543848..1544105	+	258	WP_003413167.1	ribbon-helix-helix domain-containing protein	Antitoxin
FOC59_RS07170	1544102..1544479	+	378	WP_003413174.1	type II toxin-antitoxin system VapC family toxin	-
FOC59_RS07175	1544495..1544869	-	375	WP_003413177.1	hypothetical protein	-
FOC59_RS07180	1544969..1545364	-	396	WP_003413180.1	type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20	-
FOC59_RS07185	1545361..1545606	-	246	WP_003413183.1	type II toxin-antitoxin system antitoxin VapB20	-
FOC59_RS07190	1546017..1546436	-	420	WP_003413190.1	A24 family peptidase	-
FOC59_RS07195	1546448..1547257	-	810	WP_003413193.1	shikimate dehydrogenase	-
FOC59_RS07200	1547254..1548510	-	1257	WP_014585306.1	endolytic transglycosylase MltG	-
FOC59_RS07205	1548503..1549015	-	513	WP_003413197.1	Holliday junction resolvase RuvX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15045.00 Da
• Isoelectric Point: 5.4673

>T143900 WP_003413164.1 NZ_CP046308:1543396-1543809 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Nucleotide

• Length: 414 bp

>T143900 NZ_CP061404:339025-339393 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9453.63 Da
• Isoelectric Point: 10.6555

>AT143900 WP_003413167.1 NZ_CP046308:1543848-1544105 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Nucleotide

• Length: 258 bp

>AT143900 NZ_CP061404:338807-339028 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: G0TQ26

Antitoxin

• AlphaFold DB: A0A829C9W5