143897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 1077799..1078328 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag FOC59_RS04970 Protein ID WP_003411124.1
Coordinates 1077799..1078116 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag FOC59_RS04975 Protein ID WP_003411127.1
Coordinates 1078113..1078328 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS04940 1072936..1074012 + 1077 WP_003907870.1 hypothetical protein -
FOC59_RS04945 1074009..1074290 + 282 WP_003411112.1 hypothetical protein -
FOC59_RS04950 1074326..1075399 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
FOC59_RS04955 1075404..1075934 - 531 WP_003903767.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
FOC59_RS04960 1075982..1077328 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
FOC59_RS04970 1077799..1078116 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC59_RS04975 1078113..1078328 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
FOC59_RS04980 1078583..1079641 + 1059 WP_003411129.1 hypothetical protein -
FOC59_RS04985 1079771..1080127 - 357 WP_003411130.1 hypothetical protein -
FOC59_RS04990 1080222..1081004 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
FOC59_RS04995 1081272..1081562 - 291 WP_003900476.1 YggT family protein -
FOC59_RS05000 1081724..1082380 - 657 WP_003411133.1 cell division protein SepF -
FOC59_RS05005 1082446..1083222 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T143897 WP_003411124.1 NZ_CP046308:c1078116-1077799 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T143897 NZ_CP061399:c5407989-5407606 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT143897 WP_003411127.1 NZ_CP046308:c1078328-1078113 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT143897 NZ_CP061399:c5408231-5407989 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References