Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 869881..870425 Replicon chromosome
Accession NZ_CP046308
Organism Mycobacterium tuberculosis strain FDAARGOS_751

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag FOC59_RS03950 Protein ID WP_003409896.1
Coordinates 869881..870177 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag FOC59_RS03955 Protein ID WP_003409899.1
Coordinates 870174..870425 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC59_RS03895 864914..865264 - 351 WP_003409871.1 hypothetical protein -
FOC59_RS03900 865275..866177 - 903 WP_003409874.1 hypothetical protein -
FOC59_RS03905 866198..866389 - 192 WP_003409876.1 hypothetical protein -
FOC59_RS03910 866390..866686 - 297 WP_003409877.1 hypothetical protein -
FOC59_RS03915 866926..867141 + 216 WP_003409878.1 antitoxin -
FOC59_RS03920 867138..867449 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FOC59_RS20905 867423..867944 - 522 WP_003904745.1 hypothetical protein -
FOC59_RS03930 867919..868296 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
FOC59_RS03935 868338..868787 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
FOC59_RS03940 868784..869329 + 546 WP_003409891.1 SecB-like chaperone -
FOC59_RS03945 869218..869832 - 615 WP_003901296.1 hypothetical protein -
FOC59_RS03950 869881..870177 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC59_RS03955 870174..870425 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FOC59_RS03960 870412..870906 + 495 WP_003899099.1 hypothetical protein -
FOC59_RS03965 871066..871473 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FOC59_RS03970 871477..871749 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FOC59_RS03975 871782..873002 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
FOC59_RS03980 873901..874698 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T143889 WP_003409896.1 NZ_CP046308:c870177-869881 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T143889 NZ_CP061399:739306-739791 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT143889 WP_003409899.1 NZ_CP046308:c870425-870174 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT143889 NZ_CP061399:739016-739309 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References