Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1885572..1886367 Replicon chromosome
Accession NZ_CP046306
Organism Staphylococcus hominis strain FDAARGOS_746

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag FOC54_RS09730 Protein ID WP_017176399.1
Coordinates 1886200..1886367 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag FOC54_RS09725 Protein ID WP_002449669.1
Coordinates 1885572..1886171 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC54_RS09705 1881388..1882842 + 1455 WP_155975544.1 ABC transporter substrate-binding protein/permease -
FOC54_RS09710 1882835..1883557 + 723 WP_049431519.1 amino acid ABC transporter ATP-binding protein -
FOC54_RS09715 1883819..1884940 + 1122 WP_049334938.1 tRNA epoxyqueuosine(34) reductase QueG -
FOC54_RS09720 1884942..1885412 + 471 WP_002449676.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
FOC54_RS09725 1885572..1886171 + 600 WP_002449669.1 glucosamine-6-phosphate isomerase Antitoxin
FOC54_RS09730 1886200..1886367 + 168 WP_017176399.1 hypothetical protein Toxin
FOC54_RS09735 1886478..1886870 + 393 WP_002449658.1 hypothetical protein -
FOC54_RS09740 1887011..1888396 + 1386 WP_049334939.1 class II fumarate hydratase -
FOC54_RS09745 1888475..1889299 - 825 WP_155975545.1 RluA family pseudouridine synthase -
FOC54_RS09750 1889437..1890546 + 1110 WP_002455149.1 GAF domain-containing sensor histidine kinase -
FOC54_RS09755 1890561..1891184 + 624 WP_002449659.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6478.81 Da        Isoelectric Point: 3.9837

>T143878 WP_017176399.1 NZ_CP046306:1886200-1886367 [Staphylococcus hominis]
MSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Download         Length: 168 bp

>T143878 NZ_CP061396:871186-871596 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22389.25 Da        Isoelectric Point: 4.9712

>AT143878 WP_002449669.1 NZ_CP046306:1885572-1886171 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT143878 NZ_CP061396:870939-871205 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References