Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1756485..1757014 Replicon chromosome
Accession NZ_CP046306
Organism Staphylococcus hominis strain FDAARGOS_746

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag FOC54_RS08965 Protein ID WP_017174798.1
Coordinates 1756652..1757014 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag FOC54_RS08960 Protein ID WP_002448681.1
Coordinates 1756485..1756655 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC54_RS08935 1752390..1752869 + 480 WP_155975502.1 PH domain-containing protein -
FOC54_RS08940 1752859..1754361 + 1503 WP_070715875.1 PH domain-containing protein -
FOC54_RS08945 1754354..1754833 + 480 WP_133945447.1 PH domain-containing protein -
FOC54_RS08950 1754858..1755211 + 354 WP_019835621.1 holo-ACP synthase -
FOC54_RS08955 1755254..1756399 + 1146 WP_002448692.1 alanine racemase -
FOC54_RS08960 1756485..1756655 + 171 WP_002448681.1 hypothetical protein Antitoxin
FOC54_RS08965 1756652..1757014 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOC54_RS08970 1757386..1758387 + 1002 WP_002448679.1 PP2C family protein-serine/threonine phosphatase -
FOC54_RS08975 1758473..1758799 + 327 WP_002448686.1 anti-sigma factor antagonist -
FOC54_RS08980 1758801..1759280 + 480 WP_155975503.1 anti-sigma B factor RsbW -
FOC54_RS08985 1759255..1760025 + 771 WP_002455074.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T143877 WP_017174798.1 NZ_CP046306:1756652-1757014 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T143877 NZ_CP061396:738123-738608 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT143877 WP_002448681.1 NZ_CP046306:1756485-1756655 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT143877 NZ_CP061396:737833-738126 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References