Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1745468..1745986 Replicon chromosome
Accession NZ_CP046306
Organism Staphylococcus hominis strain FDAARGOS_746

Toxin (Protein)


Gene name TsdT Uniprot ID A0A6B8SK15
Locus tag FOC54_RS08905 Protein ID WP_002448674.1
Coordinates 1745777..1745986 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag FOC54_RS08900 Protein ID WP_002437530.1
Coordinates 1745468..1745761 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC54_RS08875 1740691..1741479 + 789 WP_155975496.1 hydroxyethylthiazole kinase -
FOC54_RS08880 1741482..1742120 + 639 WP_048787784.1 thiamine phosphate synthase -
FOC54_RS08885 1742209..1743078 + 870 WP_155975497.1 membrane protein insertase YidC -
FOC54_RS08890 1743136..1743783 - 648 WP_155975498.1 HD domain-containing protein -
FOC54_RS08895 1743818..1745302 - 1485 WP_070468338.1 cardiolipin synthase -
FOC54_RS08900 1745468..1745761 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
FOC54_RS08905 1745777..1745986 + 210 WP_002448674.1 heavy-metal-associated domain-containing protein Toxin
FOC54_RS08910 1746099..1746236 + 138 WP_002437525.1 hypothetical protein -
FOC54_RS08915 1746397..1747581 - 1185 WP_002455068.1 rod shape-determining protein RodA -
FOC54_RS08920 1747957..1749027 + 1071 WP_155975499.1 D-alanine--D-alanine ligase -
FOC54_RS08925 1749043..1750398 + 1356 WP_155975500.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7956.00 Da        Isoelectric Point: 4.0857

>T143876 WP_002448674.1 NZ_CP046306:1745777-1745986 [Staphylococcus hominis]
MLNSNIVFIDNIETEEQAQMLNERLLNMIGVHTVSIDIERNKINVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T143876 NZ_CP061396:351787-352134 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT143876 WP_002437530.1 NZ_CP046306:1745468-1745761 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT143876 NZ_CP061396:352134-352433 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B8SK15

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References