Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 385327..386139 Replicon chromosome
Accession NZ_CP046306
Organism Staphylococcus hominis strain FDAARGOS_746

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag FOC54_RS02215 Protein ID WP_155974913.1
Coordinates 385675..386139 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag FOC54_RS02210 Protein ID WP_131566277.1
Coordinates 385327..385662 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC54_RS11865 382184..382354 - 171 WP_196774448.1 hypothetical protein -
FOC54_RS02185 382374..382688 - 315 WP_155974909.1 DUF771 domain-containing protein -
FOC54_RS02190 382736..382927 + 192 WP_155974910.1 hypothetical protein -
FOC54_RS02195 383076..383843 - 768 WP_131566283.1 ParB N-terminal domain-containing protein -
FOC54_RS02200 383843..384766 - 924 WP_196774449.1 ParB N-terminal domain-containing protein -
FOC54_RS02205 384905..385150 - 246 WP_155974912.1 helix-turn-helix domain-containing protein -
FOC54_RS02210 385327..385662 + 336 WP_131566277.1 helix-turn-helix transcriptional regulator Antitoxin
FOC54_RS02215 385675..386139 + 465 WP_155974913.1 ImmA/IrrE family metallo-endopeptidase Toxin
FOC54_RS02220 386155..386832 + 678 WP_155974914.1 hypothetical protein -
FOC54_RS02225 386880..387932 + 1053 WP_155974915.1 site-specific integrase -
FOC54_RS02230 388227..388847 - 621 WP_155974916.1 hypothetical protein -
FOC54_RS02235 388935..390176 - 1242 WP_155974917.1 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 344061..391181 47120


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(33-121)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-68)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18044.67 Da        Isoelectric Point: 5.2800

>T143875 WP_155974913.1 NZ_CP046306:385675-386139 [Staphylococcus hominis]
VGKYEDMLIEHDYIEVIECDNLPKKLSGLWLGDMILINRNLPITSKLETLAEELAHNELTYGSIVDQTSFNHRKFEGYAR
RLAYEKLVPLKDIVKAFLQGIHNLYELANFFEVTESFVLQSIEHYKQKYGCSTRCGNYVIQFEPLRVFEYKNID

Download         Length: 465 bp

>T143875 NZ_CP061396:325817-326185 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12872.26 Da        Isoelectric Point: 5.2538

>AT143875 WP_131566277.1 NZ_CP046306:385327-385662 [Staphylococcus hominis]
MTKFSDNLSNLRKANNYSLKELSDRLNSKYNVKFSKASIDRWEKGTTSPSMEHASALSDFFRVSLDELSGREELVVEEKP
NHLAAHLDGDLTDDEWQEILDYAEYIRSKRK

Download         Length: 336 bp

>AT143875 NZ_CP061396:325599-325820 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References