143874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2124506..2125301 Replicon chromosome
Accession NZ_CP046301
Organism Staphylococcus hominis strain FDAARGOS_747

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag FOC55_RS10575 Protein ID WP_002449670.1
Coordinates 2125134..2125301 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag FOC55_RS10570 Protein ID WP_002455147.1
Coordinates 2124506..2125105 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC55_RS10550 2120322..2121776 + 1455 WP_002455144.1 ABC transporter substrate-binding protein/permease -
FOC55_RS10555 2121769..2122491 + 723 WP_065581340.1 amino acid ABC transporter ATP-binding protein -
FOC55_RS10560 2122753..2123874 + 1122 WP_049334938.1 tRNA epoxyqueuosine(34) reductase QueG -
FOC55_RS10565 2123876..2124346 + 471 WP_002449676.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
FOC55_RS10570 2124506..2125105 + 600 WP_002455147.1 hypothetical protein Antitoxin
FOC55_RS10575 2125134..2125301 + 168 WP_002449670.1 hypothetical protein Toxin
FOC55_RS10580 2125412..2125804 + 393 WP_002449658.1 hypothetical protein -
FOC55_RS10585 2125943..2127328 + 1386 WP_002455148.1 class II fumarate hydratase -
FOC55_RS10590 2127407..2128231 - 825 WP_002449623.1 RluA family pseudouridine synthase -
FOC55_RS10595 2128369..2129478 + 1110 WP_002488425.1 GAF domain-containing sensor histidine kinase -
FOC55_RS10600 2129493..2130116 + 624 WP_002449659.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6477.82 Da        Isoelectric Point: 4.0410

>T143874 WP_002449670.1 NZ_CP046301:2125134-2125301 [Staphylococcus hominis]
MSKDSKRNYHEDENAMVQNMNDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Download         Length: 168 bp

>T143874 NZ_CP061390:53922-54404 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22388.31 Da        Isoelectric Point: 5.3510

>AT143874 WP_002455147.1 NZ_CP046301:2124506-2125105 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNTGHLDVNIRQGLMKAREIILVVTGAKKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT143874 NZ_CP061390:53668-53934 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References