Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1995379..1995908 Replicon chromosome
Accession NZ_CP046301
Organism Staphylococcus hominis strain FDAARGOS_747

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag FOC55_RS09810 Protein ID WP_017174798.1
Coordinates 1995546..1995908 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag FOC55_RS09805 Protein ID WP_002448681.1
Coordinates 1995379..1995549 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC55_RS09780 1991284..1991763 + 480 WP_002448666.1 PH domain-containing protein -
FOC55_RS09785 1991753..1993255 + 1503 WP_155968177.1 PH domain-containing protein -
FOC55_RS09790 1993248..1993724 + 477 WP_065580927.1 PH domain-containing protein -
FOC55_RS09795 1993752..1994105 + 354 WP_002448655.1 holo-ACP synthase -
FOC55_RS09800 1994148..1995293 + 1146 WP_155968128.1 alanine racemase -
FOC55_RS09805 1995379..1995549 + 171 WP_002448681.1 hypothetical protein Antitoxin
FOC55_RS09810 1995546..1995908 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOC55_RS09815 1996280..1997281 + 1002 WP_002448679.1 PP2C family protein-serine/threonine phosphatase -
FOC55_RS09820 1997367..1997693 + 327 WP_002448686.1 anti-sigma factor antagonist -
FOC55_RS09825 1997695..1998174 + 480 WP_002448683.1 anti-sigma B factor RsbW -
FOC55_RS09830 1998149..1998919 + 771 WP_002455074.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T143873 WP_017174798.1 NZ_CP046301:1995546-1995908 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T143873 NZ_CP061389:c5369492-5369109 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT143873 WP_002448681.1 NZ_CP046301:1995379-1995549 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT143873 NZ_CP061389:c5369734-5369492 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References