Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 3124578..3125568 Replicon chromosome
Accession NZ_CP046294
Organism Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)


Gene name - Uniprot ID A0A0T9M4G2
Locus tag FOC37_RS14500 Protein ID WP_005184404.1
Coordinates 3125110..3125568 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9M4Z0
Locus tag FOC37_RS14495 Protein ID WP_005184401.1
Coordinates 3124578..3125024 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC37_RS14475 3120238..3120945 + 708 WP_032906074.1 murein tripeptide amidase MpaA -
FOC37_RS14480 3120942..3121913 - 972 WP_032906075.1 L-Ala-D/L-Glu epimerase -
FOC37_RS14485 3122067..3122570 + 504 WP_005184397.1 thiol peroxidase -
FOC37_RS14490 3122683..3124260 - 1578 WP_005184399.1 transcriptional regulator TyrR -
FOC37_RS14495 3124578..3125024 + 447 WP_005184401.1 DUF2384 domain-containing protein Antitoxin
FOC37_RS14500 3125110..3125568 + 459 WP_005184404.1 RES family NAD+ phosphorylase Toxin
FOC37_RS14505 3125594..3126655 - 1062 WP_032906077.1 YcjF family protein -
FOC37_RS14510 3126652..3128049 - 1398 WP_032906079.1 YcjX family protein -
FOC37_RS14515 3128030..3128269 - 240 WP_005184410.1 phage shock protein PspD -
FOC37_RS14520 3128378..3128752 - 375 WP_005184415.1 envelope stress response membrane protein PspC -
FOC37_RS14525 3128752..3128979 - 228 WP_032906081.1 envelope stress response membrane protein PspB -
FOC37_RS14530 3129123..3129788 - 666 WP_005184417.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17201.65 Da        Isoelectric Point: 4.8938

>T143858 WP_005184404.1 NZ_CP046294:3125110-3125568 [Yersinia intermedia]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALSFAFDPRLK

Download         Length: 459 bp

>T143858 NZ_CP061385:c4768038-4767505 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16256.70 Da        Isoelectric Point: 9.1234

>AT143858 WP_005184401.1 NZ_CP046294:3124578-3125024 [Yersinia intermedia]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp

>AT143858 NZ_CP061385:c4768315-4768049 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9M4G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M4Z0

References