Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1529734..1530409 Replicon chromosome
Accession NZ_CP046294
Organism Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)


Gene name cptA Uniprot ID A0A0T9MA63
Locus tag FOC37_RS06990 Protein ID WP_032908006.1
Coordinates 1529981..1530409 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9M975
Locus tag FOC37_RS06985 Protein ID WP_005193092.1
Coordinates 1529734..1530000 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC37_RS06965 1525894..1526643 + 750 WP_005193105.1 SDR family oxidoreductase -
FOC37_RS06970 1526705..1527313 - 609 WP_005193102.1 HD domain-containing protein -
FOC37_RS06975 1527668..1528318 + 651 WP_005193099.1 hemolysin III family protein -
FOC37_RS06980 1528376..1529368 - 993 WP_005193095.1 tRNA-modifying protein YgfZ -
FOC37_RS06985 1529734..1530000 + 267 WP_005193092.1 FAD assembly factor SdhE Antitoxin
FOC37_RS06990 1529981..1530409 + 429 WP_032908006.1 protein YgfX Toxin
FOC37_RS06995 1530406..1531101 + 696 WP_032908003.1 two-component system response regulator CreB -
FOC37_RS07000 1531129..1532556 + 1428 WP_032906548.1 two-component system sensor histidine kinase CreC -
FOC37_RS07005 1532649..1534055 + 1407 WP_005185995.1 cell envelope integrity protein CreD -
FOC37_RS07010 1534106..1534624 - 519 WP_005185992.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16529.42 Da        Isoelectric Point: 10.3815

>T143856 WP_032908006.1 NZ_CP046294:1529981-1530409 [Yersinia intermedia]
VAQWRCDLRVSWHTQLFSLLSHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNLVLWKRL
EWIVVKQPWITRYGVLLNLQQSSSRSARKRLWLAADSMSEDEWRQLCLLLRHSFGSDKGMNQ

Download         Length: 429 bp

>T143856 NZ_CP061385:c3921252-3921150 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10462.96 Da        Isoelectric Point: 5.1405

>AT143856 WP_005193092.1 NZ_CP046294:1529734-1530000 [Yersinia intermedia]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT143856 NZ_CP061385:3921143-3921288 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9MA63

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M975

References