Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1228013..1228479 Replicon chromosome
Accession NZ_CP046294
Organism Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9MGJ2
Locus tag FOC37_RS05560 Protein ID WP_032906934.1
Coordinates 1228013..1228288 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0T9MGP0
Locus tag FOC37_RS05565 Protein ID WP_032906933.1
Coordinates 1228288..1228479 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC37_RS05545 1223037..1225304 + 2268 WP_005188260.1 DNA topoisomerase IV subunit A -
FOC37_RS05550 1225527..1226267 + 741 WP_005188255.1 1-acylglycerol-3-phosphate O-acyltransferase -
FOC37_RS05555 1226439..1227866 + 1428 WP_005188253.1 cell division protein FtsP -
FOC37_RS05560 1228013..1228288 - 276 WP_032906934.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FOC37_RS05565 1228288..1228479 - 192 WP_032906933.1 hypothetical protein Antitoxin
FOC37_RS05570 1228650..1230920 + 2271 WP_005188248.1 YgiQ family radical SAM protein -
FOC37_RS05575 1230942..1231775 - 834 WP_005188245.1 2,5-didehydrogluconate reductase DkgA -
FOC37_RS05580 1232092..1233249 - 1158 WP_005188243.1 alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10442.91 Da        Isoelectric Point: 4.7385

>T143855 WP_032906934.1 NZ_CP046294:c1228288-1228013 [Yersinia intermedia]
MLPIKWTDEAKTDLYALIAFITEENPYAAESLLHQLEDSVLPATEHPYMFRSGRVPGTREIVAHPNYVIIYQVMADQISV
LNVVHSRQEYP

Download         Length: 276 bp

>T143855 NZ_CP061385:c3301281-3299959 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7164.16 Da        Isoelectric Point: 7.0117

>AT143855 WP_032906933.1 NZ_CP046294:c1228479-1228288 [Yersinia intermedia]
MSTKLSPIVSEFETEEQAESYDLWFRAKVEASMNSPKPQTPHDEVMAGARKIIEQAKARRKLA

Download         Length: 192 bp

>AT143855 NZ_CP061385:c3301547-3301281 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9MGJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9MGP0

References