Detailed information of TA system TA143853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1024685..1026314
• Replicon: chromosome
• Accession: NZ_CP046294
• Organism: Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FOC37_RS04610
• Protein ID: WP_155967538.1
• Coordinates: 1024685..1026013 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0T9MED0
• Locus tag: FOC37_RS04615
• Protein ID: WP_005191449.1
• Coordinates: 1026015..1026314 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC37_RS04595	1020109..1020462	+	354	WP_032907677.1	MmcQ/YjbR family DNA-binding protein	-
FOC37_RS04600	1020601..1023432	-	2832	WP_005191457.1	excinuclease ABC subunit UvrA	-
FOC37_RS04605	1023833..1024381	+	549	WP_005191456.1	single-stranded DNA-binding protein SSB1	-
FOC37_RS04610	1024685..1026013	-	1329	WP_155967538.1	type II toxin-antitoxin system HipA family toxin	Toxin
FOC37_RS04615	1026015..1026314	-	300	WP_005191449.1	helix-turn-helix transcriptional regulator	Antitoxin
FOC37_RS04620	1026585..1027253	+	669	WP_005191448.1	glutathione S-transferase	-
FOC37_RS04625	1027624..1028991	+	1368	WP_005191447.1	NCS2 family permease	-
FOC37_RS04630	1029210..1030859	+	1650	WP_005191446.1	Na+/H+ antiporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	965103..1033884	68781

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (155-405)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-66)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 50194.07 Da
• Isoelectric Point: 6.7730

>T143853 WP_155967538.1 NZ_CP046294:c1026013-1024685 [Yersinia intermedia]
MTRRIQRLNIWMNGQYVGYWEKTRGEESLVYAQEWIENAQGRPLSLSLPFTANNQVYRGNIVRDYFDNLLPDSDDIRRRL
ATRYHADSINPFDLLFELGRDCVGAIQLLANDTPPADLFSIQQQPLTEHDVARILRNSWSDNTFVRPEHNEDLRLSIAGA
QEKTALLFHDDRWCLPLGSTPTTHIFKLPLGLVGNMQADMRTSVENEWLCAKILASYNLPVARSEIGQFEDQKALIVERF
DRRLSRDNRWIVRLPQEDMCQASGTSPLKKYQMDGGPGITTIMGILSGSDNASEDRNLFFKTQIIFWLLAATDGHAKNFS
IAHLPRNSYHLTPLYDVLSTHPIIGSSHNQIAIQKAKLAMAVRGSENYYLINQIQRRHWRKQAELVGLGAYLADSIIDEV
ITATPRVIAQIQAQLPANFPTDLAESILTGLHRQCDKIAAMP

Nucleotide

• Length: 1329 bp

>T143853 NZ_CP061385:740213-740698 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11268.02 Da
• Isoelectric Point: 9.4879

>AT143853 WP_005191449.1 NZ_CP046294:c1026314-1026015 [Yersinia intermedia]
MDYPIKILSQLRPTLIGFRKQKGLTQASLAQLLGITQQSYAKLEADPASASIERLFKVLQLLDVELILSEKKNVRLYSSK
THQPEESQTLNLPSKQEDW

Nucleotide

• Length: 300 bp

>AT143853 NZ_CP061385:739923-740216 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0T9MED0