Detailed information of TA system TA143852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1010597..1011561
• Replicon: chromosome
• Accession: NZ_CP046294
• Organism: Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FOC37_RS04555
• Protein ID: WP_155967532.1
• Coordinates: 1011154..1011561 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: FOC37_RS04550
• Protein ID: WP_155967530.1
• Coordinates: 1010597..1011157 (+)
• Length: 187 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC37_RS04530	1007678..1009051	+	1374	WP_155967524.1	hypothetical protein	-
FOC37_RS04535	1009051..1009686	+	636	WP_155967526.1	tail fiber assembly protein	-
FOC37_RS04540	1009742..1009987	-	246	WP_155967528.1	DinI-like family protein	-
FOC37_RS04545	1009998..1010240	-	243	WP_155967969.1	hypothetical protein	-
FOC37_RS04550	1010597..1011157	+	561	WP_155967530.1	SocA family protein	Antitoxin
FOC37_RS04555	1011154..1011561	+	408	WP_155967532.1	hypothetical protein	Toxin
FOC37_RS04560	1011582..1012670	-	1089	WP_155967534.1	site-specific integrase	-
FOC37_RS04565	1012760..1013809	+	1050	WP_155967536.1	tRNA dihydrouridine(20/20a) synthase DusA	-
FOC37_RS04570	1014124..1014342	+	219	WP_005191465.1	envelope stress response protein PspG	-
FOC37_RS04575	1014632..1015615	-	984	WP_005191463.1	quinone oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	965103..1033884	68781

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (27-140)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15333.68 Da
• Isoelectric Point: 6.7306

>T143852 WP_155967532.1 NZ_CP046294:1011154-1011561 [Yersinia intermedia]
MTEAYDPYRKGTVLAPSGPHNHLHIICSDPIYNQEFGCDCVLVVNICSIPTSGIHDPACVLQAGEHAFIKHPSYLLYRLS
VLWRVPVLCNKVDSGEYKTYDDINELTFKKIIQGFSDSDFTPFKIVRFIEKNKLI

Nucleotide

• Length: 408 bp

>T143852 NZ_CP061385:352722-353069 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 187 a.a.
• Molecular weight: 21605.76 Da
• Isoelectric Point: 5.6710

>AT143852 WP_155967530.1 NZ_CP046294:1010597-1011157 [Yersinia intermedia]
MFSEERVAQMAAYLLHKRGGRMAYLKLMKLLYLSDRQSMEMYGEPISGDRYVSMDKGPVLSRTLSLITGGGDVPNHGWDK
WIRGERDHNVSLKIKFEDLSDLDELCRADMKAMDAIYEKYGHWNRFDLCEQTHRICPEWQDPDGSSIPIKTKDIFMALGK
DVNEAEELTRILQDRDQLVKMTLDLR

Nucleotide

• Length: 561 bp

>AT143852 NZ_CP061385:353069-353368 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA