Detailed information of TA system TA143851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 628785..629367
• Replicon: chromosome
• Accession: NZ_CP046294
• Organism: Yersinia intermedia strain FDAARGOS_729

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FOC37_RS02860
• Protein ID: WP_005186844.1
• Coordinates: 628785..629075 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0T9ML19
• Locus tag: FOC37_RS02865
• Protein ID: WP_032906763.1
• Coordinates: 629086..629367 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC37_RS02835	624064..625227	+	1164	WP_005186836.1	mannitol-1-phosphate 5-dehydrogenase	-
FOC37_RS02840	625409..625963	+	555	WP_005186837.1	MltR family transcriptional regulator	-
FOC37_RS02845	625965..626573	-	609	WP_032906751.1	LysE family translocator	-
FOC37_RS02850	626789..628270	+	1482	WP_032906752.1	PLP-dependent aminotransferase family protein	-
FOC37_RS02855	628363..628719	+	357	WP_005186841.1	YibL family ribosome-associated protein	-
FOC37_RS02860	628785..629075	-	291	WP_005186844.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FOC37_RS02865	629086..629367	-	282	WP_032906763.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FOC37_RS02870	629469..630143	-	675	WP_005186847.1	6-N-hydroxylaminopurine resistance protein	-
FOC37_RS02875	630287..632248	-	1962	WP_005186851.1	methyl-accepting chemotaxis protein	-
FOC37_RS02880	632643..633263	-	621	WP_032906754.1	superoxide dismutase [Mn]	-
FOC37_RS02885	633388..634242	-	855	WP_005186854.1	formate dehydrogenase accessory sulfurtransferase FdhD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-87)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11249.86 Da
• Isoelectric Point: 6.8695

>T143851 WP_005186844.1 NZ_CP046294:c629075-628785 [Yersinia intermedia]
MPRTADYTKDFLKDWERLSRSGRYDMYRLKHAMLLLIANDTPLGAEWLDHPLKGDWENFRECHIGGDFLLIYKLSSSSKI
SQIIFVRAGTHSELFD

Nucleotide

• Length: 291 bp

>T143851 NZ_CP061385:326751-327119 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10371.76 Da
• Isoelectric Point: 5.0859

>AT143851 WP_032906763.1 NZ_CP046294:c629367-629086 [Yersinia intermedia]
MATHTTMLHVRIDDDVKKQATAALNAMGLSVSDAVRLFLNRVVADQAFPFELKVPNPQTRAAMQEAEEIVQAHSARFTTS
DELFIELEKDNSK

Nucleotide

• Length: 282 bp

>AT143851 NZ_CP061385:326533-326754 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0T9ML19