Detailed information of TA system TA143850

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 4806854..4807436
• Replicon: chromosome
• Accession: NZ_CP046293
• Organism: Yersinia intermedia strain FDAARGOS_730

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FOC38_RS22205
• Protein ID: WP_005186844.1
• Coordinates: 4806854..4807144 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0T9ML19
• Locus tag: FOC38_RS22210
• Protein ID: WP_032906763.1
• Coordinates: 4807155..4807436 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC38_RS22180	4802133..4803296	+	1164	WP_005186836.1	mannitol-1-phosphate 5-dehydrogenase	-
FOC38_RS22185	4803478..4804032	+	555	WP_005186837.1	MltR family transcriptional regulator	-
FOC38_RS22190	4804034..4804642	-	609	WP_032906751.1	LysE family translocator	-
FOC38_RS22195	4804858..4806339	+	1482	WP_032906752.1	PLP-dependent aminotransferase family protein	-
FOC38_RS22200	4806432..4806788	+	357	WP_005186841.1	YibL family ribosome-associated protein	-
FOC38_RS22205	4806854..4807144	-	291	WP_005186844.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FOC38_RS22210	4807155..4807436	-	282	WP_032906763.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FOC38_RS22215	4807538..4808212	-	675	WP_005186847.1	6-N-hydroxylaminopurine resistance protein	-
FOC38_RS22220	4808356..4810317	-	1962	WP_005186851.1	methyl-accepting chemotaxis protein	-
FOC38_RS22225	4810712..4811332	-	621	WP_032906754.1	superoxide dismutase [Mn]	-
FOC38_RS22230	4811457..4812311	-	855	WP_005186854.1	formate dehydrogenase accessory sulfurtransferase FdhD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-87)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11249.86 Da
• Isoelectric Point: 6.8695

>T143850 WP_005186844.1 NZ_CP046293:c4807144-4806854 [Yersinia intermedia]
MPRTADYTKDFLKDWERLSRSGRYDMYRLKHAMLLLIANDTPLGAEWLDHPLKGDWENFRECHIGGDFLLIYKLSSSSKI
SQIIFVRAGTHSELFD

Nucleotide

• Length: 291 bp

>T143850 NZ_CP061382:c68735-68319 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10371.76 Da
• Isoelectric Point: 5.0859

>AT143850 WP_032906763.1 NZ_CP046293:c4807436-4807155 [Yersinia intermedia]
MATHTTMLHVRIDDDVKKQATAALNAMGLSVSDAVRLFLNRVVADQAFPFELKVPNPQTRAAMQEAEEIVQAHSARFTTS
DELFIELEKDNSK

Nucleotide

• Length: 282 bp

>AT143850 NZ_CP061382:c68962-68732 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0T9ML19