Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2373737..2374727 Replicon chromosome
Accession NZ_CP046293
Organism Yersinia intermedia strain FDAARGOS_730

Toxin (Protein)


Gene name - Uniprot ID A0A0T9M4G2
Locus tag FOC38_RS11200 Protein ID WP_005184404.1
Coordinates 2374269..2374727 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9M4Z0
Locus tag FOC38_RS11195 Protein ID WP_005184401.1
Coordinates 2373737..2374183 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC38_RS11175 2369397..2370104 + 708 WP_032906074.1 murein tripeptide amidase MpaA -
FOC38_RS11180 2370101..2371072 - 972 WP_032906075.1 L-Ala-D/L-Glu epimerase -
FOC38_RS11185 2371226..2371729 + 504 WP_005184397.1 thiol peroxidase -
FOC38_RS11190 2371842..2373419 - 1578 WP_005184399.1 transcriptional regulator TyrR -
FOC38_RS11195 2373737..2374183 + 447 WP_005184401.1 DUF2384 domain-containing protein Antitoxin
FOC38_RS11200 2374269..2374727 + 459 WP_005184404.1 RES family NAD+ phosphorylase Toxin
FOC38_RS11205 2374753..2375814 - 1062 WP_032906077.1 YcjF family protein -
FOC38_RS11210 2375811..2377208 - 1398 WP_032906079.1 YcjX family protein -
FOC38_RS11215 2377189..2377428 - 240 WP_005184410.1 phage shock protein PspD -
FOC38_RS11220 2377537..2377911 - 375 WP_005184415.1 envelope stress response membrane protein PspC -
FOC38_RS11225 2377911..2378138 - 228 WP_032906081.1 envelope stress response membrane protein PspB -
FOC38_RS11230 2378282..2378947 - 666 WP_005184417.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-145)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17201.65 Da        Isoelectric Point: 4.8938

>T143840 WP_005184404.1 NZ_CP046293:2374269-2374727 [Yersinia intermedia]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSNIMLLQPQ
DWPLDWRNDPAPAATMDIGTEWLESESSIGLLVPSTLVPSEHNMLVNPRHKDFQACLSTAKALSFAFDPRLK

Download         Length: 459 bp

>T143840 NZ_CP061380:807710-808120 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16256.70 Da        Isoelectric Point: 9.1234

>AT143840 WP_005184401.1 NZ_CP046293:2373737-2374183 [Yersinia intermedia]
MRAYQPTPTTKAGALWREIGLPASRGTVLVDSIKLGFSVDVIDSIHLWASMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAIVWMSTPIKGLGHRSPDSLLETETGALEICDLIGRLEHGVFS

Download         Length: 447 bp

>AT143840 NZ_CP061380:807463-807729 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9M4G2

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M4Z0

References