Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1131544..1132163 Replicon chromosome
Accession NZ_CP046293
Organism Yersinia intermedia strain FDAARGOS_730

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag FOC38_RS05335 Protein ID WP_002208622.1
Coordinates 1131544..1131747 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0T9M685
Locus tag FOC38_RS05340 Protein ID WP_005182270.1
Coordinates 1131795..1132163 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC38_RS05320 1127617..1127859 + 243 WP_025378177.1 hypothetical protein -
FOC38_RS05325 1127908..1128321 + 414 WP_025376910.1 hypothetical protein -
FOC38_RS05330 1129694..1130467 + 774 WP_050108922.1 hypothetical protein -
FOC38_RS05335 1131544..1131747 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
FOC38_RS05340 1131795..1132163 - 369 WP_005182270.1 Hha toxicity modulator TomB Antitoxin
FOC38_RS05345 1132322..1132675 - 354 WP_032905603.1 hypothetical protein -
FOC38_RS05350 1133449..1134186 + 738 WP_050073470.1 ABC transporter ATP-binding protein -
FOC38_RS05355 1134183..1135040 + 858 WP_032905605.1 metal ABC transporter permease -
FOC38_RS05360 1135069..1135947 + 879 WP_005182278.1 metal ABC transporter substrate-binding protein -
FOC38_RS05365 1136114..1136257 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
FOC38_RS05370 1136260..1136532 - 273 WP_032905607.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1120608..1132675 12067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T143839 WP_002208622.1 NZ_CP046293:c1131747-1131544 [Yersinia intermedia]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T143839 NZ_CP061380:729547-730032 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14222.93 Da        Isoelectric Point: 4.4314

>AT143839 WP_005182270.1 NZ_CP046293:c1132163-1131795 [Yersinia intermedia]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDDGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYTCTLMKT

Download         Length: 369 bp

>AT143839 NZ_CP061380:729257-729550 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M685

References