Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 778893..779568 Replicon chromosome
Accession NZ_CP046293
Organism Yersinia intermedia strain FDAARGOS_730

Toxin (Protein)


Gene name cptA Uniprot ID A0A0T9MA63
Locus tag FOC38_RS03685 Protein ID WP_032908006.1
Coordinates 779140..779568 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9M975
Locus tag FOC38_RS03680 Protein ID WP_005193092.1
Coordinates 778893..779159 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC38_RS03660 775053..775802 + 750 WP_005193105.1 SDR family oxidoreductase -
FOC38_RS03665 775864..776472 - 609 WP_005193102.1 HD domain-containing protein -
FOC38_RS03670 776827..777477 + 651 WP_005193099.1 hemolysin III family protein -
FOC38_RS03675 777535..778527 - 993 WP_005193095.1 tRNA-modifying protein YgfZ -
FOC38_RS03680 778893..779159 + 267 WP_005193092.1 FAD assembly factor SdhE Antitoxin
FOC38_RS03685 779140..779568 + 429 WP_032908006.1 protein YgfX Toxin
FOC38_RS03690 779565..780260 + 696 WP_032908003.1 two-component system response regulator CreB -
FOC38_RS03695 780288..781715 + 1428 WP_032906548.1 two-component system sensor histidine kinase CreC -
FOC38_RS03700 781808..783214 + 1407 WP_005185995.1 cell envelope integrity protein CreD -
FOC38_RS03705 783265..783783 - 519 WP_005185992.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16529.42 Da        Isoelectric Point: 10.3815

>T143838 WP_032908006.1 NZ_CP046293:779140-779568 [Yersinia intermedia]
VAQWRCDLRVSWHTQLFSLLSHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNLVLWKRL
EWIVVKQPWITRYGVLLNLQQSSSRSARKRLWLAADSMSEDEWRQLCLLLRHSFGSDKGMNQ

Download         Length: 429 bp

>T143838 NZ_CP061380:350625-350972 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10462.96 Da        Isoelectric Point: 5.1405

>AT143838 WP_005193092.1 NZ_CP046293:778893-779159 [Yersinia intermedia]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT143838 NZ_CP061380:350972-351271 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATGGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9MA63

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9M975

References