Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 477172..477638 Replicon chromosome
Accession NZ_CP046293
Organism Yersinia intermedia strain FDAARGOS_730

Toxin (Protein)


Gene name relE Uniprot ID A0A0T9MGJ2
Locus tag FOC38_RS02255 Protein ID WP_032906934.1
Coordinates 477172..477447 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0T9MGP0
Locus tag FOC38_RS02260 Protein ID WP_032906933.1
Coordinates 477447..477638 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC38_RS02240 472196..474463 + 2268 WP_005188260.1 DNA topoisomerase IV subunit A -
FOC38_RS02245 474686..475426 + 741 WP_005188255.1 1-acylglycerol-3-phosphate O-acyltransferase -
FOC38_RS02250 475598..477025 + 1428 WP_005188253.1 cell division protein FtsP -
FOC38_RS02255 477172..477447 - 276 WP_032906934.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FOC38_RS02260 477447..477638 - 192 WP_032906933.1 hypothetical protein Antitoxin
FOC38_RS02265 477809..480079 + 2271 WP_005188248.1 YgiQ family radical SAM protein -
FOC38_RS02270 480101..480934 - 834 WP_005188245.1 2,5-didehydrogluconate reductase DkgA -
FOC38_RS02275 481251..482408 - 1158 WP_005188243.1 alcohol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10442.91 Da        Isoelectric Point: 4.7385

>T143837 WP_032906934.1 NZ_CP046293:c477447-477172 [Yersinia intermedia]
MLPIKWTDEAKTDLYALIAFITEENPYAAESLLHQLEDSVLPATEHPYMFRSGRVPGTREIVAHPNYVIIYQVMADQISV
LNVVHSRQEYP

Download         Length: 276 bp

>T143837 NZ_CP061380:324656-325024 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7164.16 Da        Isoelectric Point: 7.0117

>AT143837 WP_032906933.1 NZ_CP046293:c477638-477447 [Yersinia intermedia]
MSTKLSPIVSEFETEEQAESYDLWFRAKVEASMNSPKPQTPHDEVMAGARKIIEQAKARRKLA

Download         Length: 192 bp

>AT143837 NZ_CP061380:324438-324659 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9MGJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9MGP0

References