Detailed information of TA system TA143833

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 4838459..4838943
• Replicon: chromosome
• Accession: NZ_CP046286
• Organism: Shigella sonnei strain FDAARGOS_715

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A377EAU1
• Locus tag: FOC23_RS25250
• Protein ID: WP_014334020.1
• Coordinates: 4838653..4838943 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: A0A376K4R9
• Locus tag: FOC23_RS25245
• Protein ID: WP_005142544.1
• Coordinates: 4838459..4838653 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC23_RS25205 (4833654)	4833654..4834010	-	357	WP_005140877.1	hypothetical protein	-
FOC23_RS25210 (4834068)	4834068..4834490	-	423	WP_001151171.1	DUF977 family protein	-
FOC23_RS25215 (4834506)	4834506..4835231	-	726	WP_000450631.1	DUF1627 domain-containing protein	-
FOC23_RS25220 (4835253)	4835253..4835999	-	747	WP_000788740.1	ATP-binding protein	-
FOC23_RS25225 (4836006)	4836006..4837070	-	1065	WP_001262380.1	hypothetical protein	-
FOC23_RS25230 (4837142)	4837142..4837567	-	426	WP_000693826.1	toxin YdaT family protein	-
FOC23_RS25235 (4837564)	4837564..4837827	-	264	WP_001048456.1	helix-turn-helix transcriptional regulator	-
FOC23_RS25240 (4837954)	4837954..4838439	+	486	WP_053002468.1	helix-turn-helix domain-containing protein	-
FOC23_RS25245 (4838459)	4838459..4838653	+	195	WP_005142544.1	hypothetical protein	Antitoxin
FOC23_RS25250 (4838653)	4838653..4838943	+	291	WP_014334020.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC23_RS25255 (4839222)	4839222..4839374	+	153	WP_000379558.1	DUF1391 family protein	-
FOC23_RS25260 (4839386)	4839386..4839751	+	366	WP_024174355.1	hypothetical protein	-
FOC23_RS25270 (4841129)	4841129..4841917	+	789	Protein_4749	Rha family transcriptional regulator	-
FOC23_RS25280 (4842666)	4842666..4843742	+	1077	Protein_4751	molybdopterin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4831607..4860221	28614

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11062.93 Da
• Isoelectric Point: 10.2013

>T143833 WP_014334020.1 NZ_CP046286:4838653-4838943 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Nucleotide

• Length: 291 bp

>T143833 NZ_CP061379:1211246-1211617 [Bradyrhizobium genosp. B]
ATGAAAGTCCTGGCGGATACGTCGATCTGGGTCGACCACCTCCGCCGCGCGGATGAGCGGCTGGCTGGTCTCCTCAATCA
CGGGGATATCGTCATTCATCCGTTCGTGATCGGGGAATTGCTTCTAGGGGGCGTGCCCAAGGGCTCCGATATGCTTGACG
ATCTGAACACTCTCCCCAGGGCGACGGTCGCAGGCAATGACGAAGTCCTGGAGTTCATCGTCAAACGAAGGCTAACCGGG
TTGGGCATCGGATACGTCGATGCGCACTTGCTGGCGTCGACGATTTTGACGGCCGAGGCCTCAATCTGGACACGCGATAA
GCGGTTGCTTGCGGCGGCTCGGTCGCTGAACCTGGCTGCCGATATCCAATGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7097.98 Da
• Isoelectric Point: 4.1759

>AT143833 WP_005142544.1 NZ_CP046286:4838459-4838653 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Nucleotide

• Length: 195 bp

>AT143833 NZ_CP061379:1211058-1211249 [Bradyrhizobium genosp. B]
ATGAGAACCACGATCGCGATCGACGACGAGCTCTTTGCCAAGGCGCAGGAGTTCGCTGGTGTCAGTGAAAAGTCGGCTGT
TGTCAGGGAAGCTTTGAAGGCCTTCGTCGAACGAGAGGCCGCGCGCCGTCTCGCACGGATGGGAGGTACCGAACCCAAGG
TTAAGGCTCCGCCGCGTCGCCGACCCAAATGA

Structures

Toxin

• AlphaFold DB: A0A377EAU1

Antitoxin

• AlphaFold DB: A0A376K4R9