Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3624016..3624634 Replicon chromosome
Accession NZ_CP046286
Organism Shigella sonnei strain FDAARGOS_715

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FOC23_RS19080 Protein ID WP_001291435.1
Coordinates 3624016..3624234 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag FOC23_RS19085 Protein ID WP_000344804.1
Coordinates 3624260..3624634 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC23_RS19045 (3619308) 3619308..3619880 + 573 WP_000779812.1 YbaY family lipoprotein -
FOC23_RS19050 (3619911) 3619911..3620222 - 312 WP_000409911.1 MGMT family protein -
FOC23_RS19060 (3620601) 3620601..3620954 + 354 WP_000878140.1 DUF1428 domain-containing protein -
FOC23_RS19065 (3620996) 3620996..3622544 - 1549 Protein_3522 cyclic-guanylate-specific phosphodiesterase PdeB -
FOC23_RS19070 (3622708) 3622708..3623178 - 471 WP_000136192.1 YlaC family protein -
FOC23_RS19075 (3623294) 3623294..3623845 - 552 WP_000102564.1 maltose O-acetyltransferase -
FOC23_RS19080 (3624016) 3624016..3624234 - 219 WP_001291435.1 HHA domain-containing protein Toxin
FOC23_RS19085 (3624260) 3624260..3624634 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
FOC23_RS19090 (3625180) 3625180..3628329 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
FOC23_RS19095 (3628352) 3628352..3629545 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T143824 WP_001291435.1 NZ_CP046286:c3624234-3624016 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T143824 NZ_CP061376:c5359211-5358933 [Pseudomonas aeruginosa]
GTGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT143824 WP_000344804.1 NZ_CP046286:c3624634-3624260 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT143824 NZ_CP061376:c5358921-5358616 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References