Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1485559..1486213 Replicon chromosome
Accession NZ_CP046286
Organism Shigella sonnei strain FDAARGOS_715

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag FOC23_RS08650 Protein ID WP_000244777.1
Coordinates 1485559..1485966 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FOC23_RS08655 Protein ID WP_000354046.1
Coordinates 1485947..1486213 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC23_RS08630 (1481516) 1481516..1483249 - 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -
FOC23_RS08635 (1483255) 1483255..1483965 - 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FOC23_RS08640 (1483990) 1483990..1484886 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FOC23_RS08645 (1484998) 1484998..1485519 + 522 WP_001055874.1 flavodoxin FldB -
FOC23_RS08650 (1485559) 1485559..1485966 - 408 WP_000244777.1 protein YgfX Toxin
FOC23_RS08655 (1485947) 1485947..1486213 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FOC23_RS08660 (1486456) 1486456..1487436 + 981 WP_000886060.1 tRNA-modifying protein YgfZ -
FOC23_RS08665 (1487632) 1487632..1488291 - 660 WP_000250274.1 hemolysin III family protein -
FOC23_RS08670 (1488455) 1488455..1488766 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
FOC23_RS08675 (1488811) 1488811..1490244 + 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
FOC23_RS08680 (1490301) 1490301..1491044 - 744 WP_000951938.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T143818 WP_000244777.1 NZ_CP046286:c1485966-1485559 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T143818 NZ_CP061375:3359946-3360227 [Xanthomonas oryzae pv. oryzae]
GTGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCGCATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCAGCGCGGCCAGTACAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT143818 WP_000354046.1 NZ_CP046286:c1486213-1485947 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT143818 NZ_CP061375:3360245-3360535 [Xanthomonas oryzae pv. oryzae]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References