Detailed information of TA system TA143808

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3699205..3699862
• Replicon: chromosome
• Accession: NZ_CP046271
• Organism: Enterobacter hormaechei strain E70

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: GMA21_RS17640
• Protein ID: WP_058652631.1
• Coordinates: 3699205..3699615 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: GMA21_RS17645
• Protein ID: WP_003863437.1
• Coordinates: 3699596..3699862 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GMA21_RS17620	3695203..3696936	-	1734	WP_003863445.1	single-stranded-DNA-specific exonuclease RecJ	-
GMA21_RS17625	3696942..3697655	-	714	WP_003863443.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
GMA21_RS17630	3697684..3698580	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
GMA21_RS17635	3698682..3699203	+	522	WP_003863440.1	flavodoxin FldB	-
GMA21_RS17640	3699205..3699615	-	411	WP_058652631.1	protein YgfX	Toxin
GMA21_RS17645	3699596..3699862	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
GMA21_RS17650	3700157..3701137	+	981	WP_003863435.1	tRNA-modifying protein YgfZ	-
GMA21_RS17655	3701223..3701882	-	660	WP_003863433.1	hemolysin III family protein	-
GMA21_RS17660	3702149..3702880	+	732	WP_003863431.1	MurR/RpiR family transcriptional regulator	-
GMA21_RS17665	3702997..3704430	+	1434	WP_003863430.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16367.25 Da
• Isoelectric Point: 11.6602

>T143808 WP_058652631.1 NZ_CP046271:c3699615-3699205 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIRLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T143808 NZ_CP061369:c3343306-3343031 [Komagataeibacter rhaeticus]
ATGACCTGTGTTTCCTATACCGACCTGCGCCAGAATCTGGCACATTATCTGGACGAAGCCGTGAACAGCCGCGCGCCGAT
TGTCGTGACCCGCAAGACCGGGAAAGGCAGTGTCGTGCTGATGTCGGAAGAAGAATTCTCTGGCTGGCAGGAAACCGTGC
ATCTTCTGAGCAGCCCACGCAACGCGGAAAGGCTGTTGCGGAGCATTCGTGACATCGAGCATGGGGCGGCGACCGAGCGT
GATCTTCTGGAGCCGCAGGATGAACCGTCGGCGTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT143808 WP_003863437.1 NZ_CP046271:c3699862-3699596 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT143808 NZ_CP061369:c3343034-3342765 [Komagataeibacter rhaeticus]
GTGAAGGTCATTTTTCATGAAGATGGCTGGGAGGATTATCTTTCCTGGTTCCAGTCAGATCATGCTGTTCTTGGGAAGGT
TAATGCCCTGATCGAGGATGTAAGGCGGCATCCGTTTCAGGGGATAGGGAAGCCAGAACCACTGAAGGGGCAGCTTTCCG
GGTGGTGGTCCCGACGGATTACGGGGGAACATCGTCTGGTCTACCGGGTTCAGGGCCGCGCGGGAGAGGATCAGCGGATC
GAGGTTGCCCAGTGCCGGTTTCATTACTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5