Detailed information of TA system TA143807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3023229..3025012
• Replicon: chromosome
• Accession: NZ_CP046271
• Organism: Enterobacter hormaechei strain E70

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GMA21_RS14530
• Protein ID: WP_058652848.1
• Coordinates: 3023229..3024578 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: GMA21_RS14535
• Protein ID: WP_003859317.1
• Coordinates: 3024575..3025012 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GMA21_RS14505	3019052..3019987	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
GMA21_RS14510	3020156..3020551	+	396	WP_003859308.1	CidA/LrgA family protein	-
GMA21_RS14515	3020548..3021243	+	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
GMA21_RS14520	3021372..3022256	+	885	WP_003859312.1	cytidine deaminase	-
GMA21_RS14525	3022384..3023094	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
GMA21_RS14530	3023229..3024578	+	1350	WP_058652848.1	type II toxin-antitoxin system HipA family toxin	Toxin
GMA21_RS14535	3024575..3025012	+	438	WP_003859317.1	helix-turn-helix domain-containing protein	Antitoxin
GMA21_RS14540	3025051..3026061	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
GMA21_RS14545	3026077..3027597	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
GMA21_RS14550	3027677..3028675	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
GMA21_RS14555	3028971..3029993	-	1023	WP_003859324.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51151.81 Da
• Isoelectric Point: 4.6562

>T143807 WP_058652848.1 NZ_CP046271:3023229-3024578 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESIPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T143807 NZ_CP061369:c3343034-3342765 [Komagataeibacter rhaeticus]
GTGAAGGTCATTTTTCATGAAGATGGCTGGGAGGATTATCTTTCCTGGTTCCAGTCAGATCATGCTGTTCTTGGGAAGGT
TAATGCCCTGATCGAGGATGTAAGGCGGCATCCGTTTCAGGGGATAGGGAAGCCAGAACCACTGAAGGGGCAGCTTTCCG
GGTGGTGGTCCCGACGGATTACGGGGGAACATCGTCTGGTCTACCGGGTTCAGGGCCGCGCGGGAGAGGATCAGCGGATC
GAGGTTGCCCAGTGCCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT143807 WP_003859317.1 NZ_CP046271:3024575-3025012 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT143807 NZ_CP061369:c3343306-3343031 [Komagataeibacter rhaeticus]
ATGACCTGTGTTTCCTATACCGACCTGCGCCAGAATCTGGCACATTATCTGGACGAAGCCGTGAACAGCCGCGCGCCGAT
TGTCGTGACCCGCAAGACCGGGAAAGGCAGTGTCGTGCTGATGTCGGAAGAAGAATTCTCTGGCTGGCAGGAAACCGTGC
ATCTTCTGAGCAGCCCACGCAACGCGGAAAGGCTGTTGCGGAGCATTCGTGACATCGAGCATGGGGCGGCGACCGAGCGT
GATCTTCTGGAGCCGCAGGATGAACCGTCGGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9