Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2214143..2214882 Replicon chromosome
Accession NZ_CP046271
Organism Enterobacter hormaechei strain E70

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag GMA21_RS10645 Protein ID WP_003857133.1
Coordinates 2214143..2214628 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag GMA21_RS10650 Protein ID WP_003857131.1
Coordinates 2214616..2214882 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMA21_RS10625 2210296..2211054 - 759 WP_155961078.1 trans-aconitate 2-methyltransferase -
GMA21_RS10630 2211139..2211723 - 585 WP_001190898.1 GDP-mannose pyrophosphatase nudK -
GMA21_RS10635 2211810..2212568 + 759 WP_117308965.1 DeoR/GlpR family DNA-binding transcription regulator -
GMA21_RS10640 2212673..2213965 + 1293 WP_058652202.1 glycoside hydrolase -
GMA21_RS10645 2214143..2214628 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
GMA21_RS10650 2214616..2214882 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
GMA21_RS10655 2214946..2215875 - 930 WP_003857129.1 LysR family transcriptional regulator -
GMA21_RS10660 2216005..2217393 + 1389 WP_023314162.1 MFS transporter -
GMA21_RS10665 2217415..2218410 - 996 WP_003857125.1 DUF2891 domain-containing protein -
GMA21_RS10670 2218420..2219406 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T143798 WP_003857133.1 NZ_CP046271:c2214628-2214143 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T143798 NZ_CP061368:c2247225-2245900 [Wenzhouxiangella sp. AB-CW3]
GTGAGTACGGTAGCCGAAGTCCGGCTGTGGGGGCGCACCATTGGTGCCGTTGCCCTGATGGACGGGGAGCAGACGGCCGT
TTTCGAGTACGCGCCTGCATTCATCGGCAGCGGGATCGAGGTCGCTCCGCTGACCATGCCGCTGTCTGATCGGGTCTTCC
GCTTTCCCGAGTTGTCCCGGCAGACATTTCACGGCTTGCCCGGGTTGCTGGCCGACTCGCTGCCCGACAAGTTCGGCCAT
CTGCTGATCAATGCCTGGCTGGCCCGGCAGGGGCGCTCACCCGGCTCGATGAATGCGGTCGAGCGCCTCTGCTATACCGG
CCGGCGCGGCATGGGCGCACTGGAGTTCGAGCCTCGACTTGGTCCGAAGGCTCGTGAGTCACGTCACCTCGAGGTGGATG
CGCTGGTCGAGCTGGCGTCTGAGGTGCTCAGTCAGCGCGATGAGCTGCAGGCCAGTTTCGGCGAGGACACCAGCGAACAG
GCCATGGCCGATATCCTGCGCGTGGGGACCTCGGCTGGCGGTGCCAGGGCCAAGGCGGTCGTGGCCTGGAATCCCGAGAC
CGGCGAAGTGCGTTCCGGCCAGGTCGATCACGGCGCGGGATTCGAGCACTGGTTGCTGAAGTTCGATGGCGTGAGCGGCA
ACCGTGATCGCGAGCTGGATGATCCGCAGGGATATGGTGCCATTGAGTATGCCTATCACTTGATGGCTGTGGATGCCGGG
ATTGAGATGACTGAGTGCCGCCTGCTCGAGGAGAACGGCCGCCGGCATTTCATGACCCGGCGATTTGATCGGACATCCGA
TGGCGGCAAGCTGCACATGCAGTCGCTGTGTGCCATGGCCCACTTCGACTACAACCTGCCGGGTGCCTATAGTTATGAGC
AGGCCTTTCAGATCATGCGTCAGCTTGGCTTGTCCATGTCCGAGCTGGAACAGTTCTATCGTCGCGCCGTTTTCAATATC
CTCGGCCGCAACCAGGACGATCATGTCAAGAACATTGCTTTCCTGATGGATCGGCACGGCCAATGGCGCCTTTCGCCGGT
CTTCGACCTGGTTTTCAGCTACAACCCGGAAGGTGACTGGACGGCCCGCCACCAGATGACGCTCAATGGTCGACGCGATC
ACTTCAGTTTTGATGATTTCCGCTCACTGGCCGCTGCCGCCGGGCTCAAGCGGGGCCGGGAGCGGCTGATCTTCAACGAG
GTCCGCTCCTGTCTGCTGGACTGGCCGCACTACGCCAGCCGTGCCGGATTGCCGGCAGCGACTGCACGCCGTATCGAGCA
ATTGCTGCGTGCCGAGGACGTCAGCCCCGGAAAGTCGGGCTATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT143798 WP_003857131.1 NZ_CP046271:c2214882-2214616 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT143798 NZ_CP061368:c2247578-2247222 [Wenzhouxiangella sp. AB-CW3]
ATGAGTATTGCAAATACAATGTCCGATGAAGCGGTGTTGGCCGAGCTGGGGCGGCGGCTGGCGCAGCGGCGGCTGGCGCT
TCGTCTGAGTCAGGCCGAGCTGGCCGAACGGGCCGGTGTGGGCAAGCGCACGGTCGAACGTATCGAGGCGGGGCAGTCGG
CGCAGATGACCAGTGTGGTCCGGCTGCTGCGCGTGCTGGAGCTGATGCCGGCGCTCGATGCCATGATTCCGGCCGAAACC
GTGCGTCCGATGACCCTGCTCAAGCAGGGCGGCAAGCTGCCGCAACGGGTACGCAAGCGCGATGATGAGCAACAGGTGCG
GGAGGCTGGGTCCTGGGCCTGGGGTGAGTCCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References