Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1053244..1053864 Replicon chromosome
Accession NZ_CP046271
Organism Enterobacter hormaechei strain E70

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag GMA21_RS05020 Protein ID WP_015571250.1
Coordinates 1053244..1053462 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag GMA21_RS05025 Protein ID WP_006809850.1
Coordinates 1053490..1053864 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMA21_RS04990 1049256..1049516 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
GMA21_RS04995 1049519..1049659 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GMA21_RS05000 1049656..1050366 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
GMA21_RS05005 1050468..1051928 + 1461 WP_058652690.1 PLP-dependent aminotransferase family protein -
GMA21_RS05010 1051900..1052367 - 468 WP_022650495.1 hypothetical protein -
GMA21_RS05015 1052484..1053035 - 552 WP_022650496.1 maltose O-acetyltransferase -
GMA21_RS05020 1053244..1053462 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
GMA21_RS05025 1053490..1053864 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
GMA21_RS05030 1054375..1057521 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
GMA21_RS05035 1057544..1058737 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T143797 WP_015571250.1 NZ_CP046271:c1053462-1053244 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T143797 NZ_CP061368:c1897753-1897415 [Wenzhouxiangella sp. AB-CW3]
ATGAAGCGTGGTGAGATCTGGTGGGCGTCGTTGCCTGAGCCGACCGGATCCGGTCCTGGTTTCCGACGCCCTGTTCTGGT
TGTCCAGTCCAATCCATTCAATTCCAGTCGAATTGCAACGGTCGTGGTCGCGGCCATTACCTCCAACCTTCGGCTTTCAG
CCGCGCCGGGTAACGCGAGAATCACGAAACGGGAGTCGGGTCTCGGAAAGGCTTCCGTCGTCAATGTCAGTCAGGTTCTC
ACCCTGGACCGCACACGGCTGACCGAACAGGTGCGGCGGCTGTCTGAAAAGAGAATGCTCGAAATAGATCAAGGCCTTCG
GGTGGTCCTCGGGCTGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT143797 WP_006809850.1 NZ_CP046271:c1053864-1053490 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT143797 NZ_CP061368:c1897976-1897740 [Wenzhouxiangella sp. AB-CW3]
ATGAAAGTAGCGATTTCCGTTCCGGATCCAGTATTCCAGGCCGCTGAGCAATTCGCAAAGGAGCGAGGGATTCCCCGTAG
CCAGCTTTTTGCGGAGGCGCTGGAGGAGTACCTGGCGCAACACGGGCCCGAGGCGATTACGGCTCAACTGAATCGGGTTC
ATGATTCTGAAAAGTCGAAGCTCGATGAGTCATTCATTCGAGCTCAGTCAGCCGTGTTGAAAGATGAAGCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References