Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 885935..886587 Replicon chromosome
Accession NZ_CP046269
Organism Vibrio spartinae strain 3.6

Toxin (Protein)


Gene name hicA Uniprot ID A0A1N6LZR6
Locus tag Vspart_RS20445 Protein ID WP_074371264.1
Coordinates 886408..886587 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1M4V002
Locus tag Vspart_RS20440 Protein ID WP_021021012.1
Coordinates 885935..886348 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Vspart_RS20415 881490..882128 - 639 WP_139302084.1 hypothetical protein -
Vspart_RS20420 882261..882863 - 603 WP_074371260.1 hypothetical protein -
Vspart_RS20425 883022..883495 - 474 WP_182288785.1 GrpB family protein -
Vspart_RS20430 883601..884179 - 579 WP_074371262.1 hypothetical protein -
Vspart_RS20435 884767..885648 - 882 WP_182288786.1 HEPN domain-containing protein -
Vspart_RS20440 885935..886348 - 414 WP_021021012.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Vspart_RS20445 886408..886587 - 180 WP_074371264.1 type II toxin-antitoxin system HicA family toxin Toxin
Vspart_RS20450 886946..887227 - 282 WP_182288787.1 hypothetical protein -
Vspart_RS20455 887253..887438 - 186 WP_162493844.1 hypothetical protein -
Vspart_RS20460 887514..887861 - 348 WP_074371307.1 cupin domain-containing protein -
Vspart_RS20465 888266..889942 - 1677 WP_182288788.1 glycoside hydrolase family 11 protein -
Vspart_RS20470 890754..891044 - 291 WP_182288789.1 YkgJ family cysteine cluster protein -
Vspart_RS20475 891194..891397 - 204 WP_182288790.1 4-oxalocrotonate tautomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6663.87 Da        Isoelectric Point: 11.0775

>T143795 WP_074371264.1 NZ_CP046269:c886587-886408 [Vibrio spartinae]
VKSADLINLLKKNGWELVSVRGSHHKFRHPAHDDPIIVPHPKKDLKIGLVNKIKRQAGL

Download         Length: 180 bp

>T143795 NZ_CP061368:1568196-1568477 [Wenzhouxiangella sp. AB-CW3]
ATGATTCGCAGCTTTGCCGACCGCGAAACCCGAGTGATCTGGGAAGGTCGGCAGTCGCGAAAGCTGCCTGCTAACATTCA
GGCAACCGCCCGGCGAAAGCTGCGAATGTTGAATAATGCACGTGACCTGACTGATTTGCGGGTTCCGCCGGGAAACCGGC
TGGAGGCTCTGAAAGGGAACCGTGTCGGTCAATACAGTATCAGAATCAATGACCAGTGGCGCATTTGCTTCAAATGGCAA
GACAATGCAGCTGCCGAGGTTGAAATCGTGGACTATCATTAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15259.33 Da        Isoelectric Point: 4.5544

>AT143795 WP_021021012.1 NZ_CP046269:c886348-885935 [Vibrio spartinae]
MLYPIAIDTGDKEHAYGVTFPDLPGCFSAGDTLDEALLNAKDAAEFYLEDLAEHGKLPPKAGDLSTWQKDPEYLGWAWAV
VDIDVEPFLGKSIKINATLPTLYLKKIDDLVKVHPEYKNRSHFLQIAATHEFEKLAG

Download         Length: 414 bp

>AT143795 NZ_CP061368:1568532-1568828 [Wenzhouxiangella sp. AB-CW3]
ATGACTACCGACCGTTTGCCCAATGTTCACCCCGGAGAGATTCTACTGGAAGAGTTTCTCAAGCCTATGGGGATCAGTCA
GAATCGGCTTGCGCGAACCATAGAGGTCCCACCGAGACGGATCAATGAAATCGTGCTTGGAAAGCGACGGGTTACCGCCG
ATACGGCAATGCGCCTGGCACGAGCGTTTGGAACCTCGGAACGCTTTTGGCTGGGGTTGCAAGCTGACTACGACCTTGAG
CAAGCGCACTTCGATCATGGCGAGGAAGTTCGTCGAATTCCCAACATTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1N6LZR6

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4V002

References