Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 222964..223600 Replicon chromosome
Accession NZ_CP046266
Organism Bacillus sp. DSL-17

Toxin (Protein)


Gene name mazF Uniprot ID A0A0M2PN83
Locus tag GMB29_RS01220 Protein ID WP_026562078.1
Coordinates 223250..223600 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GMB29_RS01215 Protein ID WP_136358446.1
Coordinates 222964..223245 (+) Length 94 a.a.

Genomic Context

GMB29_RS01200GMB29_RS01205GMB29_RS01210GMB29_RS01215GMB29_RS01220GMB29_RS01225GMB29_RS01230GMB29_RS01235GMB29_RS01240GMB29_RS01245GMB29_RS01250GMB29_RS01255GMB29_RS01260GMB29_RS01195
Location: 219358..219720 (363 bp)
Type: Others
Protein ID: WP_136358452.1
Location: 220064..221086 (1023 bp)
Type: Others
Protein ID: WP_136358450.1
Location: 221430..222599 (1170 bp)
Type: Others
Protein ID: WP_136358448.1
Location: 222964..223245 (282 bp)
Type: Antitoxin
Protein ID: WP_136358446.1
Location: 223250..223600 (351 bp)
Type: Toxin
Protein ID: WP_026562078.1
Location: 223737..224567 (831 bp)
Type: Others
Protein ID: WP_136358444.1
Location: 224571..224933 (363 bp)
Type: Others
Protein ID: WP_136358442.1
Location: 224937..225338 (402 bp)
Type: Others
Protein ID: WP_136358440.1
Location: 225348..226355 (1008 bp)
Type: Others
Protein ID: WP_136358438.1
Location: 226412..226744 (333 bp)
Type: Others
Protein ID: WP_136358436.1
Location: 226741..227223 (483 bp)
Type: Others
Protein ID: WP_136358434.1
Location: 227189..227980 (792 bp)
Type: Others
Protein ID: WP_136358432.1
Location: 227977..228576 (600 bp)
Type: Others
Protein ID: WP_136358430.1
Location: 218475..219197 (723 bp)
Type: Others
Protein ID: WP_136358454.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GMB29_RS01195218475..219197-723WP_136358454.1rhomboid family intramembrane serine protease-
GMB29_RS01200219358..219720+363WP_136358452.1holo-ACP synthase-
GMB29_RS01205220064..221086+1023WP_136358450.1outer membrane lipoprotein carrier protein LolA-
GMB29_RS01210221430..222599+1170WP_136358448.1alanine racemase-
GMB29_RS01215222964..223245+282WP_136358446.1antitoxin endoaiAntitoxin
GMB29_RS01220223250..223600+351WP_026562078.1type II toxin-antitoxin system endoribonuclease NdoAToxin
GMB29_RS01225223737..224567+831WP_136358444.1STAS domain-containing protein-
GMB29_RS01230224571..224933+363WP_136358442.1STAS domain-containing protein-
GMB29_RS01235224937..225338+402WP_136358440.1anti-sigma regulatory factor-
GMB29_RS01240225348..226355+1008WP_136358438.1PP2C family protein-serine/threonine phosphatase-
GMB29_RS01245226412..226744+333WP_136358436.1anti-sigma factor antagonist-
GMB29_RS01250226741..227223+483WP_136358434.1anti-sigma B factor RsbW-
GMB29_RS01255227189..227980+792WP_136358432.1RNA polymerase sigma factor SigB-
GMB29_RS01260227977..228576+600WP_136358430.1SpoIIE family protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13020.06 Da        Isoelectric Point: 4.8781

>T143787 WP_026562078.1 NZ_CP046266:223250-223600 [Bacillus sp. DSL-17]
MIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T143787 NZ_CP061367:c3559985-3559882 [Shigella sonnei]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10559.02 Da        Isoelectric Point: 5.1783

>AT143787 WP_136358446.1 NZ_CP046266:222964-223245 [Bacillus sp. DSL-17]
VSESSATTEILIQLPQALVSELDGLVKQENGNRNELIYQATKMYIRERKMRQIRESMRRGYMEMAKINLNIASEAFLAES
EADHTVERLVSGG

Download         Length: 282 bp

>AT143787 NZ_CP061367:3559881-3560115 [Shigella sonnei]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0M2PN83

Antitoxin

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Source
ID
Structure
No matching records found

References