Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 551..1110 Replicon plasmid p2974-D
Accession NZ_CP046260
Organism Escherichia coli strain ECO2947

Toxin (Protein)


Gene name relE Uniprot ID A0A1V2T4U7
Locus tag GK046_RS23660 Protein ID WP_063073486.1
Coordinates 835..1110 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V2T5E1
Locus tag GK046_RS23655 Protein ID WP_062894229.1
Coordinates 551..835 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GK046_RS23655 551..835 + 285 WP_062894229.1 ribbon-helix-helix domain-containing protein Antitoxin
GK046_RS23660 835..1110 + 276 WP_063073486.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GK046_RS23665 1377..1817 - 441 Protein_2 transposase -
GK046_RS23670 1850..3601 - 1752 Protein_3 Tn3-like element TnAs1 family transposase -
GK046_RS23675 3590..3997 + 408 WP_001214976.1 cysteine hydrolase -
GK046_RS23680 4135..5019 + 885 WP_000058717.1 EamA family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / qnrS1 / aph(6)-Id / aph(3'')-Ib / sul2 stcE / exeE / exeG 1..108424 108424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10724.40 Da        Isoelectric Point: 9.8136

>T143777 WP_063073486.1 NZ_CP046260:835-1110 [Escherichia coli]
MELKWTSKALSDLARLYDFLALASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIYAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T143777 NZ_CP061367:1094551-1094823 [Shigella sonnei]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGGGAT
CAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGTTCA
TACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGT
GACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10486.95 Da        Isoelectric Point: 5.6558

>AT143777 WP_062894229.1 NZ_CP046260:551-835 [Escherichia coli]
MQMKNNTAQVTKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLGTDNPLPVPR

Download         Length: 285 bp

>AT143777 NZ_CP061367:1094820-1095179 [Shigella sonnei]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2T4U7

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2T5E1

References