Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3958598..3959216 Replicon chromosome
Accession NZ_CP046259
Organism Escherichia coli strain ECO2947

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GK046_RS18980 Protein ID WP_001291435.1
Coordinates 3958598..3958816 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag GK046_RS18985 Protein ID WP_000344800.1
Coordinates 3958842..3959216 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GK046_RS18945 3953888..3954460 + 573 WP_000779826.1 lipoprotein -
GK046_RS18950 3954491..3954802 - 312 WP_000409911.1 MGMT family protein -
GK046_RS18960 3955181..3955534 + 354 WP_000878141.1 DUF1428 family protein -
GK046_RS18965 3955576..3957126 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
GK046_RS18970 3957290..3957760 - 471 WP_000136192.1 YlaC family protein -
GK046_RS18975 3957876..3958427 - 552 WP_000102578.1 maltose O-acetyltransferase -
GK046_RS18980 3958598..3958816 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
GK046_RS18985 3958842..3959216 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
GK046_RS18990 3959762..3962911 - 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
GK046_RS18995 3962934..3964127 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T143776 WP_001291435.1 NZ_CP046259:c3958816-3958598 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T143776 NZ_CP061367:c298588-298415 [Shigella sonnei]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT143776 WP_000344800.1 NZ_CP046259:c3959216-3958842 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT143776 NZ_CP061367:c298912-298616 [Shigella sonnei]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References